Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction

Søren Skøtt Andersen; Morten Lock Hansen; Gunnar H Gislason; Fredrik Folke; Tina Ken Schramm; Emil Fosbøl; Rikke Sørensen; Søren Rasmussen; Steen Z Abildstrøm; Mette Madsen; Lars Køber; Christian Torp-Pedersen; Søren Skøtt Andersen; Morten Lock Hansen; Gunnar H Gislason; Fredrik Folke; Tina Ken Schramm; Emil Fosbøl; Rikke Sørensen; Søren Poul Lind Rasmussen; Steen Z Abildstrøm; Mette Madsen; Lars Køber; Christian Torp-Pedersen

doi:10.1159/000143389

Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction

Søren Skøtt Andersen, Morten Lock Hansen, Gunnar H Gislason, Fredrik Folke, Tina Ken Schramm, Emil Fosbøl, Rikke Sørensen, Søren Rasmussen, Steen Z Abildstrøm, Mette Madsen, Lars Køber, Christian Torp-Pedersen, Søren Skøtt Andersen, Morten Lock Hansen, Gunnar H Gislason, Fredrik Folke, Tina Ken Schramm, Emil Fosbøl, Rikke Sørensen, Søren Poul Lind RasmussenSteen Z Abildstrøm, Mette Madsen, Lars Køber, Christian Torp-Pedersen

8 Citations (Scopus)

Abstract

Objectives: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). Methods: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. Results: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. Conclusion: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately
Udgivelsesdato: 2008/7/9

Original language	English
Journal	Cardiology
Volume	112
Issue number	2
Pages (from-to)	144-150
Number of pages	6
ISSN	0008-6312
DOIs	https://doi.org/10.1159/000143389 https://doi.org/10.1159/000143389
Publication status	Published - 2009

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Andersen, S. S., Hansen, M. L., Gislason, G. H., Folke, F., Schramm, T. K., Fosbøl, E., Sørensen, R., Rasmussen, S., Abildstrøm, S. Z., Madsen, M., Køber, L., Torp-Pedersen, C., Andersen, S. S., Hansen, M. L., Gislason, G. H., Folke, F., Schramm, T. K., Fosbøl, E., Sørensen, R., ... Torp-Pedersen, C. (2009). Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction. Cardiology, 112(2), 144-150. https://doi.org/10.1159/000143389, https://doi.org/10.1159/000143389

Andersen, SS, Hansen, ML, Gislason, GH, Folke, F, Schramm, TK, Fosbøl, E, Sørensen, R, Rasmussen, S, Abildstrøm, SZ, Madsen, M , Køber, L , Torp-Pedersen, C, Andersen, SS, Hansen, ML, Gislason, GH, Folke, F, Schramm, TK, Fosbøl, E, Sørensen, R, Rasmussen, SPL, Abildstrøm, SZ, Madsen, M, Køber, L & Torp-Pedersen, C 2009, 'Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction', Cardiology, vol. 112, no. 2, pp. 144-150. https://doi.org/10.1159/000143389, https://doi.org/10.1159/000143389

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title = "Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction",

abstract = "Objectives: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). Methods: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. Results: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. Conclusion: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately Udgivelsesdato: 2008/7/9",

author = "Andersen, {S{\o}ren Sk{\o}tt} and Hansen, {Morten Lock} and Gislason, {Gunnar H} and Fredrik Folke and Schramm, {Tina Ken} and Emil Fosb{\o}l and Rikke S{\o}rensen and S{\o}ren Rasmussen and Abildstr{\o}m, {Steen Z} and Mette Madsen and Lars K{\o}ber and Christian Torp-Pedersen and Andersen, {S{\o}ren Sk{\o}tt} and Hansen, {Morten Lock} and Gislason, {Gunnar H} and Fredrik Folke and Schramm, {Tina Ken} and Emil Fosb{\o}l and Rikke S{\o}rensen and Rasmussen, {S{\o}ren Poul Lind} and Abildstr{\o}m, {Steen Z} and Mette Madsen and Lars K{\o}ber and Christian Torp-Pedersen",

note = "Keywords: Adrenergic beta-Antagonists; Aged; Atenolol; Bisoprolol; Female; Humans; Kaplan-Meiers Estimate; Male; Metoprolol; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Recurrence; Registries; Sotalol",

year = "2009",

doi = "10.1159/000143389",

language = "English",

volume = "112",

pages = "144--150",

journal = "Cardiology",

issn = "0008-6312",

publisher = "S Karger AG",

number = "2",

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TY - JOUR

T1 - Mortality and Reinfarction among Patients Using Different Beta-Blockers for Secondary Prevention after a Myocardial Infarction

AU - Andersen, Søren Skøtt

AU - Hansen, Morten Lock

AU - Gislason, Gunnar H

AU - Folke, Fredrik

AU - Schramm, Tina Ken

AU - Fosbøl, Emil

AU - Sørensen, Rikke

AU - Rasmussen, Søren

AU - Abildstrøm, Steen Z

AU - Madsen, Mette

AU - Køber, Lars

AU - Torp-Pedersen, Christian

AU - Andersen, Søren Skøtt

AU - Hansen, Morten Lock

AU - Gislason, Gunnar H

AU - Folke, Fredrik

AU - Schramm, Tina Ken

AU - Fosbøl, Emil

AU - Sørensen, Rikke

AU - Rasmussen, Søren Poul Lind

AU - Abildstrøm, Steen Z

AU - Madsen, Mette

AU - Køber, Lars

AU - Torp-Pedersen, Christian

N1 - Keywords: Adrenergic beta-Antagonists; Aged; Atenolol; Bisoprolol; Female; Humans; Kaplan-Meiers Estimate; Male; Metoprolol; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Recurrence; Registries; Sotalol

PY - 2009

Y1 - 2009

N2 - Objectives: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). Methods: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. Results: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. Conclusion: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately Udgivelsesdato: 2008/7/9

AB - Objectives: To study differences in the clinical efficacy of various brands of beta-blocker in secondary prevention after a myocardial infarction (MI). Methods: All patients hospitalized with a first MI between 1995 and 2002 who were still alive 30 days after discharge and had had at least one prescription for a beta-blocker filled were identified by individual-level linkage of nationwide registries of hospitalizations and drugs dispensed from pharmacies. A total of 32,259 MI patients were included in the study. Multivariable Cox proportional hazard models were used to analyze the risks of death and recurrent MI related to treatment with different beta-blockers. Results: The risks for death and recurrent MI were similar in patients using different beta-blockers, except that mortality from all causes among patients with a prescription for sotalol was higher. Subgroup analyses of high-risk patients with diabetes or congestive heart failure and of patients using comparable dosages of beta-blockers did not show effects on the risk of death or recurrent MI. Conclusion: Except for sotalol, the different types of beta-blocker had similar clinical efficacy in reducing mortality and the recurrence of MI. The equivalent efficacy remained when high-risk patients were analyzed separately Udgivelsesdato: 2008/7/9

U2 - 10.1159/000143389

DO - 10.1159/000143389

M3 - Journal article

C2 - 18612201

SN - 0008-6312

VL - 112

SP - 144

EP - 150

JO - Cardiology

JF - Cardiology

IS - 2

ER -