Morbidity and mortality following poliomyelitis: a lifelong follow-up

TY - JOUR

T1 - Morbidity and mortality following poliomyelitis

T2 - a lifelong follow-up

AU - Kay, L

AU - Nielsen, N M

AU - Wanscher, B

AU - Ibsen, R

AU - Kjellberg, J

AU - Jennum, P

N1 - © 2016 EAN.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - BACKGROUND AND PURPOSE: In the world today 10-20 million people are still living with late effects of poliomyelitis (PM), but the long-term consequences of the disease are not well known. The aim of this study was to describe lifelong morbidity and mortality among Danes who survived PM.METHODS: Data from official registers for a cohort of 3606 Danes hospitalized for PM in the period 1940-1954 were compared with 13 762 age- and gender-matched controls.RESULTS: Compared with controls, mortality was moderately increased for both paralytic as well as non-paralytic PM cases; Hazard Ratio, 1.31 (95% confidence interval, 1.18-1.44) and 1.09 (95% confidence interval, 1.00-1.19), respectively. Hospitalization rates were approximately 1.5 times higher among both paralytic and non-paralytic PM cases as compared with controls. Discharge diagnoses showed a broad spectrum of diseases. There were no major differences in morbidities between paralytic and non-paralytic PM cases.CONCLUSIONS: Poliomyelitis has significant long-term consequences on morbidity and mortality of both paralytic and non-paralytic cases.

AB - BACKGROUND AND PURPOSE: In the world today 10-20 million people are still living with late effects of poliomyelitis (PM), but the long-term consequences of the disease are not well known. The aim of this study was to describe lifelong morbidity and mortality among Danes who survived PM.METHODS: Data from official registers for a cohort of 3606 Danes hospitalized for PM in the period 1940-1954 were compared with 13 762 age- and gender-matched controls.RESULTS: Compared with controls, mortality was moderately increased for both paralytic as well as non-paralytic PM cases; Hazard Ratio, 1.31 (95% confidence interval, 1.18-1.44) and 1.09 (95% confidence interval, 1.00-1.19), respectively. Hospitalization rates were approximately 1.5 times higher among both paralytic and non-paralytic PM cases as compared with controls. Discharge diagnoses showed a broad spectrum of diseases. There were no major differences in morbidities between paralytic and non-paralytic PM cases.CONCLUSIONS: Poliomyelitis has significant long-term consequences on morbidity and mortality of both paralytic and non-paralytic cases.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Paralysis/complications

KW - Poliomyelitis/epidemiology

U2 - 10.1111/ene.13201

DO - 10.1111/ene.13201

M3 - Journal article

C2 - 27869331

SN - 1351-5101

VL - 24

SP - 326

EP - 333

JO - European Journal of Neurology

JF - European Journal of Neurology

IS - 2

ER -