Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Karin K Pedersen; Ingjerd W Manner; Ingebjørg Seljeflot; Dag Kvale; Ingrid Os; Jan Gerstoft; Susanne D Nielsen; Marius Trøseid

doi:10.1097/qai.0000000000000339

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Karin K Pedersen, Ingjerd W Manner, Ingebjørg Seljeflot, Dag Kvale, Ingrid Os, Jan Gerstoft, Susanne D Nielsen, Marius Trøseid

Department of Clinical Medicine

13 Citations (Scopus)

Abstract

BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.

METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.

RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.

CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

Original language	English
Journal	Journal of acquired immune deficiency syndromes (1999)
Volume	67
Issue number	4
Pages (from-to)	370-4
Number of pages	5
ISSN	1525-4135
DOIs	https://doi.org/10.1097/qai.0000000000000339
Publication status	Published - 1 Dec 2014

Keywords

Adult
Aged
Anti-HIV Agents
Antigens, CD14
Antiretroviral Therapy, Highly Active
Arginine
Bacterial Translocation
Biological Markers
Cardiovascular Diseases
Female
Fibrin Fibrinogen Degradation Products
HIV Infections
Humans
Lipopolysaccharides
Male
Middle Aged
Monocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://pdfs.journals.lww.com/jaids/2014/12010/Monocyte_Activation,_but_not_Microbial.3.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1547408659338;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdQKVphYMSrcjlUffwiLGAnyZT8VjVUosy6sp4B6jtAbg=;hash|XH3Ki1/9Q7HVk9HaDfiW8g==

Cite this

Pedersen, K. K., Manner, I. W., Seljeflot, I., Kvale, D., Os, I., Gerstoft, J., Nielsen, S. D., & Trøseid, M. (2014). Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. Journal of acquired immune deficiency syndromes (1999), 67(4), 370-4. https://doi.org/10.1097/qai.0000000000000339

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. / Pedersen, Karin K; Manner, Ingjerd W; Seljeflot, Ingebjørg et al.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 67, No. 4, 01.12.2014, p. 370-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Pedersen, KK, Manner, IW, Seljeflot, I, Kvale, D, Os, I, Gerstoft, J, Nielsen, SD & Trøseid, M 2014, 'Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART', Journal of acquired immune deficiency syndromes (1999), vol. 67, no. 4, pp. 370-4. https://doi.org/10.1097/qai.0000000000000339

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abstract = "BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.",

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T1 - Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

AU - Pedersen, Karin K

AU - Manner, Ingjerd W

AU - Seljeflot, Ingebjørg

AU - Kvale, Dag

AU - Os, Ingrid

AU - Gerstoft, Jan

AU - Nielsen, Susanne D

AU - Trøseid, Marius

PY - 2014/12/1

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N2 - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

AB - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

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KW - Aged

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KW - Antigens, CD14

KW - Antiretroviral Therapy, Highly Active

KW - Arginine

KW - Bacterial Translocation

KW - Biological Markers

KW - Cardiovascular Diseases

KW - Female

KW - Fibrin Fibrinogen Degradation Products

KW - HIV Infections

KW - Humans

KW - Lipopolysaccharides

KW - Male

KW - Middle Aged

KW - Monocytes

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SN - 1525-4135

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ER -

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Abstract

Keywords

UN SDGs

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