Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis

M. B. Axelsen; I. Eshed; M. Østergaard; M. L. Hetland; J. M. Møller; D. V. Jensen; S. B. Krintel; M. S. Hansen; L. Terslev; M. Klarlund; R. P. Poggenborg; L. Balding; S. J. Pedersen

doi:10.1080/03009742.2016.1231338

Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis

M. B. Axelsen^*, I. Eshed, M. Østergaard, M. L. Hetland, J. M. Møller, D. V. Jensen, S. B. Krintel, M. S. Hansen, L. Terslev, M. Klarlund, R. P. Poggenborg, L. Balding, S. J. Pedersen

^*Corresponding author for this work

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

Objective: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. Methods: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses. Changes in WBMRI joint and entheses counts were investigated. Results: The readability of peripheral and axial joints was 82–100%, being less for elbows and small joints of the feet. For entheses, 72–100% were readable, except for entheses at the anterior chest wall, elbow, knee, and plantar fascia. The intrareader agreement was high for bone marrow oedema (BMO), bone erosion (80–100%), and enthesitis (77–100%), and slightly lower for synovitis and soft tissue inflammation (50–100%). All synovitis, BMO, and soft tissue inflammation counts decreased numerically during treatment. The 26-joint synovitis WBMRI count decreased significantly during the first 16 weeks for patients with a good European League Against Rheumatism (EULAR) response (from median 6 to 4, p < 0.05), but not for patients with a moderate or no EULAR response. There were no overall changes in structural lesions. Conclusions: WBMRI allows simultaneous monitoring of most axial and peripheral joints and entheses in RA patients and can visualize a decrease in inflammatory counts during treatment. This first WBMRI follow-up study of patients with RA encourages further investigation of the usefulness of WBMRI in RA.

Original language	English
Book series	Scandinavian Journal of Rheumatology
Volume	46
Issue number	4
Pages (from-to)	253-262
Number of pages	10
ISSN	0300-9742
DOIs	https://doi.org/10.1080/03009742.2016.1231338
Publication status	Published - 2017

Access to Document

10.1080/03009742.2016.1231338

Cite this

Axelsen, M. B., Eshed, I., Østergaard, M., Hetland, M. L., Møller, J. M., Jensen, D. V., Krintel, S. B., Hansen, M. S., Terslev, L., Klarlund, M., Poggenborg, R. P., Balding, L., & Pedersen, S. J. (2017). Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis. Scandinavian Journal of Rheumatology, 46(4), 253-262. https://doi.org/10.1080/03009742.2016.1231338

Monitoring total-body inflammation and damage in joints and entheses : the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis. / Axelsen, M. B.; Eshed, I.; Østergaard, M. et al.

In: Scandinavian Journal of Rheumatology, Vol. 46, No. 4, 2017, p. 253-262.

Research output: Contribution to journal › Journal article › Research › peer-review

Axelsen, MB, Eshed, I, Østergaard, M , Hetland, ML, Møller, JM, Jensen, DV, Krintel, SB, Hansen, MS, Terslev, L, Klarlund, M, Poggenborg, RP, Balding, L & Pedersen, SJ 2017, 'Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 46, no. 4, pp. 253-262. https://doi.org/10.1080/03009742.2016.1231338

@article{32ad631b578041b4a6dfd08feea30910,

title = "Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis",

abstract = "Objective: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. Methods: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses. Changes in WBMRI joint and entheses counts were investigated. Results: The readability of peripheral and axial joints was 82–100%, being less for elbows and small joints of the feet. For entheses, 72–100% were readable, except for entheses at the anterior chest wall, elbow, knee, and plantar fascia. The intrareader agreement was high for bone marrow oedema (BMO), bone erosion (80–100%), and enthesitis (77–100%), and slightly lower for synovitis and soft tissue inflammation (50–100%). All synovitis, BMO, and soft tissue inflammation counts decreased numerically during treatment. The 26-joint synovitis WBMRI count decreased significantly during the first 16 weeks for patients with a good European League Against Rheumatism (EULAR) response (from median 6 to 4, p < 0.05), but not for patients with a moderate or no EULAR response. There were no overall changes in structural lesions. Conclusions: WBMRI allows simultaneous monitoring of most axial and peripheral joints and entheses in RA patients and can visualize a decrease in inflammatory counts during treatment. This first WBMRI follow-up study of patients with RA encourages further investigation of the usefulness of WBMRI in RA.",

author = "Axelsen, {M. B.} and I. Eshed and M. {\O}stergaard and Hetland, {M. L.} and M{\o}ller, {J. M.} and Jensen, {D. V.} and Krintel, {S. B.} and Hansen, {M. S.} and L. Terslev and M. Klarlund and Poggenborg, {R. P.} and L. Balding and Pedersen, {S. J.}",

year = "2017",

doi = "10.1080/03009742.2016.1231338",

language = "English",

volume = "46",

pages = "253--262",

journal = "Acta rheumatologica Scandinavica",

issn = "0301-3847",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Monitoring total-body inflammation and damage in joints and entheses

T2 - the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis

AU - Axelsen, M. B.

AU - Eshed, I.

AU - Østergaard, M.

AU - Hetland, M. L.

AU - Møller, J. M.

AU - Jensen, D. V.

AU - Krintel, S. B.

AU - Hansen, M. S.

AU - Terslev, L.

AU - Klarlund, M.

AU - Poggenborg, R. P.

AU - Balding, L.

AU - Pedersen, S. J.

PY - 2017

Y1 - 2017

N2 - Objective: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. Methods: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses. Changes in WBMRI joint and entheses counts were investigated. Results: The readability of peripheral and axial joints was 82–100%, being less for elbows and small joints of the feet. For entheses, 72–100% were readable, except for entheses at the anterior chest wall, elbow, knee, and plantar fascia. The intrareader agreement was high for bone marrow oedema (BMO), bone erosion (80–100%), and enthesitis (77–100%), and slightly lower for synovitis and soft tissue inflammation (50–100%). All synovitis, BMO, and soft tissue inflammation counts decreased numerically during treatment. The 26-joint synovitis WBMRI count decreased significantly during the first 16 weeks for patients with a good European League Against Rheumatism (EULAR) response (from median 6 to 4, p < 0.05), but not for patients with a moderate or no EULAR response. There were no overall changes in structural lesions. Conclusions: WBMRI allows simultaneous monitoring of most axial and peripheral joints and entheses in RA patients and can visualize a decrease in inflammatory counts during treatment. This first WBMRI follow-up study of patients with RA encourages further investigation of the usefulness of WBMRI in RA.

AB - Objective: To investigate changes in whole-body magnetic resonance imaging (WBMRI) inflammatory and structural lesions in most joints and entheses in patients with rheumatoid arthritis (RA) treated with adalimumab. Methods: WBMRI was obtained at weeks 0, 6, 16, and 52 in a 52 week follow-up study of 37 RA patients starting treatment with adalimumab. Readability and reliability of WBMRI were investigated for 76 peripheral joints, 23 discovertebral units, the sacroiliac joints, and 33 entheses. Changes in WBMRI joint and entheses counts were investigated. Results: The readability of peripheral and axial joints was 82–100%, being less for elbows and small joints of the feet. For entheses, 72–100% were readable, except for entheses at the anterior chest wall, elbow, knee, and plantar fascia. The intrareader agreement was high for bone marrow oedema (BMO), bone erosion (80–100%), and enthesitis (77–100%), and slightly lower for synovitis and soft tissue inflammation (50–100%). All synovitis, BMO, and soft tissue inflammation counts decreased numerically during treatment. The 26-joint synovitis WBMRI count decreased significantly during the first 16 weeks for patients with a good European League Against Rheumatism (EULAR) response (from median 6 to 4, p < 0.05), but not for patients with a moderate or no EULAR response. There were no overall changes in structural lesions. Conclusions: WBMRI allows simultaneous monitoring of most axial and peripheral joints and entheses in RA patients and can visualize a decrease in inflammatory counts during treatment. This first WBMRI follow-up study of patients with RA encourages further investigation of the usefulness of WBMRI in RA.

U2 - 10.1080/03009742.2016.1231338

DO - 10.1080/03009742.2016.1231338

M3 - Journal article

C2 - 28125360

AN - SCOPUS:85010686537

SN - 0301-3847

VL - 46

SP - 253

EP - 262

JO - Acta rheumatologica Scandinavica

JF - Acta rheumatologica Scandinavica

IS - 4

ER -

Monitoring total-body inflammation and damage in joints and entheses: the first follow-up study of whole-body magnetic resonance imaging in rheumatoid arthritis

Abstract

Access to Document

Fingerprint

Cite this