Molecular structure and impact of amorphization strategies on intrinsic dissolution of spray dried indomethacin

Keyphrases

• Intrinsic Dissolution 100%
• Molecular Structure 100%
• Indomethacin 100%
• Amorphization 100%
• Molecular Impact 100%
• Polyvinylpyrrolidone 85%
• Hydroxypropyl-β-cyclodextrin (HP-β-CD) 71%
• Amorphous Indomethacin 42%
• Silica 42%
• Amorphous Product 28%
• Solid Dispersion 28%
• Dissolution Rate 28%
• Drug Loading 28%
• High Drug Loading 28%
• Amorphous System 28%
• Redispersion 14%
• Silica Nanoparticles (SiNPs) 14%
• Soluble Polymer 14%
• Dissolution Behavior 14%
• Good Strategies 14%
• Inclusion Complex 14%
• Property Stability 14%
• Spray Drying 14%
• Thermal Properties 14%
• Physical Stability 14%
• Colloidal Particles 14%
• Solid-state Properties 14%
• Poorly Water-soluble Drugs 14%
• Stabilizing Effect 14%
• Mass Ratio 14%
• Intrinsic Dissolution Rate 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Indometacin 100%
• Povidone 60%
• Cyclodextrin 50%
• Silicon Dioxide 30%
• Silica Nanoparticle 10%
• Colloidal Silica 10%
• Colloidal Particle 10%