Molecular Imaging with Small Animal PET/CT

T. Binderup; H.H. El-Ali; D. Skovgaard; M.M. Jensen; Fan Li; B. Hesse; J.T. Jørgensen; A. Kjær; V. Ambrosini; Tina Binderup; Henrik H. El Ali; Valentina Ambrosini; Dorthe Skovgaard; Mette Munk Jensen; Fan Li; Birger Hesse; Jesper Tranekjær Jørgensen; Andreas Kjær

doi:10.2174/157340511796411221

Molecular Imaging with Small Animal PET/CT

T. Binderup, H.H. El-Ali, D. Skovgaard, M.M. Jensen, Fan Li, B. Hesse, J.T. Jørgensen, A. Kjær, V. Ambrosini, Tina Binderup, Henrik H. El Ali, Valentina Ambrosini, Dorthe Skovgaard, Mette Munk Jensen, Fan Li, Birger Hesse, Jesper Tranekjær Jørgensen, Andreas Kjær

Endocrinology and Metabolism

8 Citations (Scopus)

Abstract

Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in pre-clinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal studies with PET and CT. However, with this achieved the possibilities are numerous and the role of pre-clinical imaging crucial for a prompt movement from bench to bedside. Several new tracers are under preclinical and clinical evaluation and most are directed at central aspects of tumor biology. We hereby present some of the recent advances in this field of small animal molecular imaging with special emphasis on the targets for tissue characterization in tumor biology such as hypoxia, proliferation and cancer specific over-expression of receptors. The added value of applying CT imaging for anatomical localization and tumor volume measurements is also described. In addition, the non-invasive nature of molecular imaging and the targets of these promising new tracers are attractive for other research areas as well, although these fields are much less explored. We present an example of an interesting research field with the application of small animal PET/CT for studies of muscle and tendon in exercise models.

Original language	English
Journal	Current Medical Imaging Reviews
Volume	7
Issue number	3
Pages (from-to)	234-47
Number of pages	14
ISSN	1573-4056
DOIs	https://doi.org/10.2174/157340511796411221
Publication status	Published - Aug 2011

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Binderup, T., El-Ali, H. H., Skovgaard, D., Jensen, M. M., Li, F., Hesse, B., Jørgensen, J. T., Kjær, A., Ambrosini, V., Binderup, T., El Ali, H. H., Ambrosini, V., Skovgaard, D., Munk Jensen, M., Li, F., Hesse, B., Jørgensen, J. T., & Kjær, A. (2011). Molecular Imaging with Small Animal PET/CT. Current Medical Imaging Reviews, 7(3), 234-47. https://doi.org/10.2174/157340511796411221

Binderup, T, El-Ali, HH, Skovgaard, D, Jensen, MM, Li, F, Hesse, B, Jørgensen, JT , Kjær, A, Ambrosini, V, Binderup, T, El Ali, HH, Ambrosini, V, Skovgaard, D, Munk Jensen, M, Li, F, Hesse, B, Jørgensen, JT & Kjær, A 2011, 'Molecular Imaging with Small Animal PET/CT', Current Medical Imaging Reviews, vol. 7, no. 3, pp. 234-47. https://doi.org/10.2174/157340511796411221

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abstract = "Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in pre-clinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal studies with PET and CT. However, with this achieved the possibilities are numerous and the role of pre-clinical imaging crucial for a prompt movement from bench to bedside. Several new tracers are under preclinical and clinical evaluation and most are directed at central aspects of tumor biology. We hereby present some of the recent advances in this field of small animal molecular imaging with special emphasis on the targets for tissue characterization in tumor biology such as hypoxia, proliferation and cancer specific over-expression of receptors. The added value of applying CT imaging for anatomical localization and tumor volume measurements is also described. In addition, the non-invasive nature of molecular imaging and the targets of these promising new tracers are attractive for other research areas as well, although these fields are much less explored. We present an example of an interesting research field with the application of small animal PET/CT for studies of muscle and tendon in exercise models.",

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Molecular Imaging with Small Animal PET/CT

Abstract

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