Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

Lone B. Madsen; Bo Thomsen; Knud Larsen; Christian Bendixen; Ida E. Holm; Merete Fredholm; Arne L. Jørgensen; Anders L. Nielsen

doi:10.1186/1471-2202-8-72

Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

Lone B. Madsen, Bo Thomsen, Knud Larsen, Christian Bendixen, Ida E. Holm, Merete Fredholm, Arne L. Jørgensen, Anders L. Nielsen

22 Citations (Scopus)

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Abstract

Background: The transmembrane presenilin (PSEN) protein, PSEN1 and PSEN2, have been proposed to be the catalytic components of the ¿-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).
Conclusion: The data provide evidence for structural and functional conservation of PSENs in mammalian lineages, and may suggest that the high sequence similarity and colocatalization of PSEN1 and PSEN2 in brain tissue reflect a certain degree of fucntional redundancy. The data show that pigs may provide a new animal model for detailed analysis of the developmental functions of the PSENs.

Original language	English
Journal	BMC Neuroscience
Volume	8
Issue number	72
Number of pages	11
ISSN	1471-2202
DOIs	https://doi.org/10.1186/1471-2202-8-72
Publication status	Published - 2007

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title = "Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain",

abstract = "Background: The transmembrane presenilin (PSEN) protein, PSEN1 and PSEN2, have been proposed to be the catalytic components of the ¿-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).Conclusion: The data provide evidence for structural and functional conservation of PSENs in mammalian lineages, and may suggest that the high sequence similarity and colocatalization of PSEN1 and PSEN2 in brain tissue reflect a certain degree of fucntional redundancy. The data show that pigs may provide a new animal model for detailed analysis of the developmental functions of the PSENs.",

author = "Madsen, {Lone B.} and Bo Thomsen and Knud Larsen and Christian Bendixen and Holm, {Ida E.} and Merete Fredholm and J{\o}rgensen, {Arne L.} and Nielsen, {Anders L.}",

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doi = "10.1186/1471-2202-8-72",

language = "English",

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T1 - Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

AU - Madsen, Lone B.

AU - Thomsen, Bo

AU - Larsen, Knud

AU - Bendixen, Christian

AU - Holm, Ida E.

AU - Fredholm, Merete

AU - Jørgensen, Arne L.

AU - Nielsen, Anders L.

PY - 2007

Y1 - 2007

N2 - Background: The transmembrane presenilin (PSEN) protein, PSEN1 and PSEN2, have been proposed to be the catalytic components of the ¿-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).Conclusion: The data provide evidence for structural and functional conservation of PSENs in mammalian lineages, and may suggest that the high sequence similarity and colocatalization of PSEN1 and PSEN2 in brain tissue reflect a certain degree of fucntional redundancy. The data show that pigs may provide a new animal model for detailed analysis of the developmental functions of the PSENs.

AB - Background: The transmembrane presenilin (PSEN) protein, PSEN1 and PSEN2, have been proposed to be the catalytic components of the ¿-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus).Conclusion: The data provide evidence for structural and functional conservation of PSENs in mammalian lineages, and may suggest that the high sequence similarity and colocatalization of PSEN1 and PSEN2 in brain tissue reflect a certain degree of fucntional redundancy. The data show that pigs may provide a new animal model for detailed analysis of the developmental functions of the PSENs.

U2 - 10.1186/1471-2202-8-72

DO - 10.1186/1471-2202-8-72

M3 - Journal article

C2 - 17854491

SN - 1471-2202

VL - 8

JO - B M C Neuroscience

JF - B M C Neuroscience

IS - 72

ER -

Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

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