Molecular biology of fuselloviruses and their satellites

TY - JOUR

T1 - Molecular biology of fuselloviruses and their satellites

AU - Contursi, Patrizia

AU - Fusco, Salvatore

AU - Cannio, Raffaele

AU - She, Qunxin

PY - 2014/5

Y1 - 2014/5

N2 - Fuselloviruses, also known as Sulfolobus Spindle-shaped viruses (SSVs), are "lemon"- or "spindle"-shaped double-stranded DNA viruses. Among them, SSV1, SSV2 and the satellite viruses pSSVx and pSSVi have been investigated at the structural, genetic, transcriptomic, proteomic and biochemical levels, thus becoming models for dissecting DNA replication/gene expression in Archaea. Important progress has been made including elucidation of temporal genome expression during virus infection and induction of replication, SSV1 lysogeny maintenance as well as differentially expression of pSSVx replicase. Future researches focusing on these model systems would yield insightful knowledge of life cycle and DNA replication of fuselloviruses.

AB - Fuselloviruses, also known as Sulfolobus Spindle-shaped viruses (SSVs), are "lemon"- or "spindle"-shaped double-stranded DNA viruses. Among them, SSV1, SSV2 and the satellite viruses pSSVx and pSSVi have been investigated at the structural, genetic, transcriptomic, proteomic and biochemical levels, thus becoming models for dissecting DNA replication/gene expression in Archaea. Important progress has been made including elucidation of temporal genome expression during virus infection and induction of replication, SSV1 lysogeny maintenance as well as differentially expression of pSSVx replicase. Future researches focusing on these model systems would yield insightful knowledge of life cycle and DNA replication of fuselloviruses.

U2 - 10.1007/s00792-014-0634-0

DO - 10.1007/s00792-014-0634-0

M3 - Journal article

C2 - 24562787

SN - 1431-0651

VL - 18

SP - 473

EP - 489

JO - Extremophiles

JF - Extremophiles

IS - 3

ER -