Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse

Redi Pecini; Morten Dalsgaard; Daniel Vega Møller; Morten Jensen; Klaus Fuglsang Kofoed; Walter Nielsen; Olav Wendelboe Nielsen; Nis Høst; Hanne Elming; Jens Peter Goetze; Christian Hassager; Lars Køber

doi:10.1111/j.1540-8175.2010.01200.x

Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse

Redi Pecini, Morten Dalsgaard, Daniel Vega Møller, Morten Jensen, Klaus Fuglsang Kofoed, Walter Nielsen, Olav Wendelboe Nielsen, Nis Høst, Hanne Elming, Jens Peter Goetze, Christian Hassager, Lars Køber

2 Citations (Scopus)

Abstract

Background: Mitral regurgitation (MR) secondary to ischemic heart disease (IHD) increases during exercise. We tested the hypothesis that the same is also true for MR due to mitral valve prolapse (MVP). Methods: Consecutive patients with asymptomatic MR of varying severity underwent exercise test on a supine bicycle with workload up to a maximum of 100 W. Echocardiographic measurements were performed at rest and at peak exercise. The study was designed to detect an effective regurgitant orifice (ERO) change of at least 10 mm² during exercise. Results: Twenty-six patients (21 male, age 56 ± 12 years (mean ± SD)) were included. Patients had an ERO of 35 ± 23 mm ² (mean ± SD) and regurgitation volume of 48 ± 38 mL (mean ± SD). In these patients, ERO remained unchanged (an increase of 2 ± 15 mm² during exercise, P = 0.6). The regurgitation volume (RVol) decreased with 11 ± 16 mL (mean ± SD), P = 0.003. When calculated for 1 minute, RVol increased during exercise (P = 0.01), but in relation to the total cardiac output it decreased significantly (P = 0.02). Conclusion: Exercise does not increase the severity of MR due to MVP, in contrast to MR secondary to IHD. Different disease mechanisms behind these two types of MR could explain this difference.

Original language	English
Journal	Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
Volume	27
Issue number	9
Pages (from-to)	1031-7
Number of pages	7
ISSN	0742-2822
DOIs	https://doi.org/10.1111/j.1540-8175.2010.01200.x
Publication status	Published - 1 Oct 2010

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Pecini, R., Dalsgaard, M., Møller, D. V., Jensen, M., Kofoed, K. F., Nielsen, W., Nielsen, O. W., Høst, N., Elming, H., Goetze, J. P., Hassager, C., & Køber, L. (2010). Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse. Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques, 27(9), 1031-7. https://doi.org/10.1111/j.1540-8175.2010.01200.x

Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse. / Pecini, Redi; Dalsgaard, Morten; Møller, Daniel Vega et al.

In: Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques, Vol. 27, No. 9, 01.10.2010, p. 1031-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Pecini, R, Dalsgaard, M, Møller, DV, Jensen, M, Kofoed, KF, Nielsen, W, Nielsen, OW, Høst, N, Elming, H, Goetze, JP , Hassager, C & Køber, L 2010, 'Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse', Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques, vol. 27, no. 9, pp. 1031-7. https://doi.org/10.1111/j.1540-8175.2010.01200.x

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title = "Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse",

abstract = "Background: Mitral regurgitation (MR) secondary to ischemic heart disease (IHD) increases during exercise. We tested the hypothesis that the same is also true for MR due to mitral valve prolapse (MVP). Methods: Consecutive patients with asymptomatic MR of varying severity underwent exercise test on a supine bicycle with workload up to a maximum of 100 W. Echocardiographic measurements were performed at rest and at peak exercise. The study was designed to detect an effective regurgitant orifice (ERO) change of at least 10 mm2 during exercise. Results: Twenty-six patients (21 male, age 56 ± 12 years (mean ± SD)) were included. Patients had an ERO of 35 ± 23 mm 2 (mean ± SD) and regurgitation volume of 48 ± 38 mL (mean ± SD). In these patients, ERO remained unchanged (an increase of 2 ± 15 mm2 during exercise, P = 0.6). The regurgitation volume (RVol) decreased with 11 ± 16 mL (mean ± SD), P = 0.003. When calculated for 1 minute, RVol increased during exercise (P = 0.01), but in relation to the total cardiac output it decreased significantly (P = 0.02). Conclusion: Exercise does not increase the severity of MR due to MVP, in contrast to MR secondary to IHD. Different disease mechanisms behind these two types of MR could explain this difference.",

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AU - Pecini, Redi

AU - Dalsgaard, Morten

AU - Møller, Daniel Vega

AU - Jensen, Morten

AU - Kofoed, Klaus Fuglsang

AU - Nielsen, Walter

AU - Nielsen, Olav Wendelboe

AU - Høst, Nis

AU - Elming, Hanne

AU - Goetze, Jens Peter

AU - Hassager, Christian

AU - Køber, Lars

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Background: Mitral regurgitation (MR) secondary to ischemic heart disease (IHD) increases during exercise. We tested the hypothesis that the same is also true for MR due to mitral valve prolapse (MVP). Methods: Consecutive patients with asymptomatic MR of varying severity underwent exercise test on a supine bicycle with workload up to a maximum of 100 W. Echocardiographic measurements were performed at rest and at peak exercise. The study was designed to detect an effective regurgitant orifice (ERO) change of at least 10 mm2 during exercise. Results: Twenty-six patients (21 male, age 56 ± 12 years (mean ± SD)) were included. Patients had an ERO of 35 ± 23 mm 2 (mean ± SD) and regurgitation volume of 48 ± 38 mL (mean ± SD). In these patients, ERO remained unchanged (an increase of 2 ± 15 mm2 during exercise, P = 0.6). The regurgitation volume (RVol) decreased with 11 ± 16 mL (mean ± SD), P = 0.003. When calculated for 1 minute, RVol increased during exercise (P = 0.01), but in relation to the total cardiac output it decreased significantly (P = 0.02). Conclusion: Exercise does not increase the severity of MR due to MVP, in contrast to MR secondary to IHD. Different disease mechanisms behind these two types of MR could explain this difference.

AB - Background: Mitral regurgitation (MR) secondary to ischemic heart disease (IHD) increases during exercise. We tested the hypothesis that the same is also true for MR due to mitral valve prolapse (MVP). Methods: Consecutive patients with asymptomatic MR of varying severity underwent exercise test on a supine bicycle with workload up to a maximum of 100 W. Echocardiographic measurements were performed at rest and at peak exercise. The study was designed to detect an effective regurgitant orifice (ERO) change of at least 10 mm2 during exercise. Results: Twenty-six patients (21 male, age 56 ± 12 years (mean ± SD)) were included. Patients had an ERO of 35 ± 23 mm 2 (mean ± SD) and regurgitation volume of 48 ± 38 mL (mean ± SD). In these patients, ERO remained unchanged (an increase of 2 ± 15 mm2 during exercise, P = 0.6). The regurgitation volume (RVol) decreased with 11 ± 16 mL (mean ± SD), P = 0.003. When calculated for 1 minute, RVol increased during exercise (P = 0.01), but in relation to the total cardiac output it decreased significantly (P = 0.02). Conclusion: Exercise does not increase the severity of MR due to MVP, in contrast to MR secondary to IHD. Different disease mechanisms behind these two types of MR could explain this difference.

U2 - 10.1111/j.1540-8175.2010.01200.x

DO - 10.1111/j.1540-8175.2010.01200.x

M3 - Journal article

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JO - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques

JF - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques

IS - 9

ER -

Moderate exercise does not increase the severity of mitral regurgitation due to mitral valve prolapse

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