Modelling synergistic effects of appetite regulating hormones

Julie Berg Schmidt; Christian Ritz

doi:10.1016/j.synres.2015.12.001

Modelling synergistic effects of appetite regulating hormones

Julie Berg Schmidt, Christian Ritz^*

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models. We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects. The link between definitions was exemplified for an appetite study where two appetite hormones were studied.

Original language	English
Journal	Synergy
Volume	3
Issue number	1
Pages (from-to)	1-2
Number of pages	2
ISSN	0838-0368
DOIs	https://doi.org/10.1016/j.synres.2015.12.001
Publication status	Published - 2016

Keywords

Analysis of covariance
Dose addition
Effect addition
Linear mixed model

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10.1016/j.synres.2015.12.001

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title = "Modelling synergistic effects of appetite regulating hormones",

abstract = "We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models. We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects. The link between definitions was exemplified for an appetite study where two appetite hormones were studied.",

keywords = "Analysis of covariance, Dose addition, Effect addition, Linear mixed model",

author = "Schmidt, {Julie Berg} and Christian Ritz",

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AU - Ritz, Christian

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AB - We briefly reviewed one definition of dose addition, which is applicable within the framework of generalized linear models. We established how this definition of dose addition corresponds to effect addition in case only two doses per compound are considered for evaluating synergistic effects. The link between definitions was exemplified for an appetite study where two appetite hormones were studied.

KW - Analysis of covariance

KW - Dose addition

KW - Effect addition

KW - Linear mixed model

U2 - 10.1016/j.synres.2015.12.001

DO - 10.1016/j.synres.2015.12.001

M3 - Letter

AN - SCOPUS:84952659358

SN - 0838-0368

VL - 3

SP - 1

EP - 2

JO - Synergy

JF - Synergy

IS - 1

ER -

Modelling synergistic effects of appetite regulating hormones

Abstract

Keywords

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