Modeling the spatial reach of the LFP

Henrik Lindén; Tom Tetzlaff; Tobias C Potjans; Klas H Pettersen; Sonja Grün; Markus Diesmann; Gaute T Einevoll

doi:10.1016/j.neuron.2011.11.006

Modeling the spatial reach of the LFP

Henrik Lindén, Tom Tetzlaff, Tobias C Potjans, Klas H Pettersen, Sonja Grün, Markus Diesmann, Gaute T Einevoll

Neuronal Signalling

226 Citations (Scopus)

Abstract

The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.

Original language	English
Journal	Neuron
Volume	72
Issue number	5
Pages (from-to)	859-72
Number of pages	14
ISSN	0896-6273
DOIs	https://doi.org/10.1016/j.neuron.2011.11.006
Publication status	Published - 8 Dec 2011

Keywords

Animals
Cerebral Cortex
Computer Simulation
Electrodes
Electroencephalography
Evoked Potentials
Humans
Models, Neurological
Nerve Net
Neurons
Synapses
Synaptic Potentials

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10.1016/j.neuron.2011.11.006

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title = "Modeling the spatial reach of the LFP",

abstract = "The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.",

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AU - Lindén, Henrik

AU - Tetzlaff, Tom

AU - Potjans, Tobias C

AU - Pettersen, Klas H

AU - Grün, Sonja

AU - Diesmann, Markus

AU - Einevoll, Gaute T

PY - 2011/12/8

Y1 - 2011/12/8

N2 - The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.

AB - The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.

KW - Animals

KW - Cerebral Cortex

KW - Computer Simulation

KW - Electrodes

KW - Electroencephalography

KW - Evoked Potentials

KW - Humans

KW - Models, Neurological

KW - Nerve Net

KW - Neurons

KW - Synapses

KW - Synaptic Potentials

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DO - 10.1016/j.neuron.2011.11.006

M3 - Journal article

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SN - 0896-6273

VL - 72

SP - 859

EP - 872

JO - Neuron

JF - Neuron

IS - 5

ER -

Modeling the spatial reach of the LFP

Abstract

Keywords

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