Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

TY - JOUR

T1 - Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

AU - Yde, Pernille

AU - Mengel, Anne Benedicte

AU - Jensen, Mogens Høgh

AU - Krishna, Sandeep

AU - Trusina, Ala

PY - 2011/7/19

Y1 - 2011/7/19

N2 - Background: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

AB - Background: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

U2 - 10.1186/1752-0509-5-115

DO - 10.1186/1752-0509-5-115

M3 - Journal article

C2 - 21771307

SN - 1752-0509

VL - 5

SP - 115

JO - BMC Systems Biology

JF - BMC Systems Biology

ER -