Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

Pernille Yde; Anne Benedicte Mengel; Mogens Høgh Jensen; Sandeep Krishna; Ala Trusina

doi:10.1186/1752-0509-5-115

Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

Pernille Yde, Anne Benedicte Mengel, Mogens Høgh Jensen, Sandeep Krishna, Ala Trusina

Biocomplexity

39 Citations (Scopus)

928 Downloads (Pure)

Abstract

Background: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

Original language	English
Journal	BMC Systems Biology
Volume	5
Pages (from-to)	115
ISSN	1752-0509
DOIs	https://doi.org/10.1186/1752-0509-5-115
Publication status	Published - 19 Jul 2011

Access to Document

10.1186/1752-0509-5-115

Modeling the...Final published version, 929 KB

Cite this

@article{6267f88cfe744b429a4368ec8a6012a9,

title = "Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue",

abstract = "Background: Waves propagating in {"}excitable media{"} is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.",

author = "Pernille Yde and Mengel, {Anne Benedicte} and Jensen, {Mogens H{\o}gh} and Sandeep Krishna and Ala Trusina",

year = "2011",

month = jul,

day = "19",

doi = "10.1186/1752-0509-5-115",

language = "English",

volume = "5",

pages = "115",

journal = "B M C Systems Biology",

issn = "1752-0509",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

AU - Yde, Pernille

AU - Mengel, Anne Benedicte

AU - Jensen, Mogens Høgh

AU - Krishna, Sandeep

AU - Trusina, Ala

PY - 2011/7/19

Y1 - 2011/7/19

N2 - Background: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

AB - Background: Waves propagating in "excitable media" is a reliable way to transmit signals in space. A fascinating example where living cells comprise such a medium is Dictyostelium D. which propagates waves of chemoattractant to attract distant cells. While neutrophils chemotax in a similar fashion as Dictyostelium D., it is unclear if chemoattractant waves exist in mammalian tissues and what mechanisms could propagate them.Results: We propose that chemoattractant cytokine waves may naturally develop as a result of NF-κB response. Using a heuristic mathematical model of NF-κB-like circuits coupled in space we show that the known characteristics of NF-κB response favor cytokine waves.Conclusions: While the propagating wave of cytokines is generally beneficial for inflammation resolution, our model predicts that there exist special conditions that can cause chronic inflammation and re-occurrence of acute inflammatory response.

U2 - 10.1186/1752-0509-5-115

DO - 10.1186/1752-0509-5-115

M3 - Journal article

C2 - 21771307

SN - 1752-0509

VL - 5

SP - 115

JO - B M C Systems Biology

JF - B M C Systems Biology

ER -

Modeling the NF-kappa B mediated inflammatory response predicts cytokine waves in tissue

Abstract

Access to Document

Fingerprint

Cite this