Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease

Yongzhong Wang; Rasmus Sejersten Ripa; Erik Jørgensen; Birger Hesse; Steen Mortensen; Jens Kastrup

doi:10.1080/14017430701601651

Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease

Yongzhong Wang, Rasmus Sejersten Ripa, Erik Jørgensen, Birger Hesse, Steen Mortensen, Jens Kastrup

6 Citations (Scopus)

Abstract

To investigate the mobilization of non-haematopoietic and haematopoietic cells from the bone marrow induced by intramyocardial VEGF gene therapy and G-CSF treatment alone or in combination in patients with chronic ischemic heart disease (IHD). Secondly, we tested the hypothesis that the quantity of circulating stem cells correlated with improvement in symptoms.

Original language	English
Journal	Scandinavian Cardiovascular Journal
Volume	41
Issue number	6
Pages (from-to)	397-404
Number of pages	8
ISSN	1401-7431
DOIs	https://doi.org/10.1080/14017430701601651
Publication status	Published - Dec 2007
Externally published	Yes

Keywords

Aged
Antigens, CD34
Antigens, CD45
Coronary Artery Disease
Female
Flow Cytometry
Genetic Therapy
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cell Mobilization
Humans
Male
Middle Aged
Treatment Outcome
Vascular Endothelial Growth Factor A

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Wang, Y., Ripa, R. S., Jørgensen, E., Hesse, B., Mortensen, S., & Kastrup, J. (2007). Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease. Scandinavian Cardiovascular Journal, 41(6), 397-404. https://doi.org/10.1080/14017430701601651

Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease. / Wang, Yongzhong; Ripa, Rasmus Sejersten; Jørgensen, Erik et al.

In: Scandinavian Cardiovascular Journal, Vol. 41, No. 6, 12.2007, p. 397-404.

Research output: Contribution to journal › Journal article › Research › peer-review

Wang, Y, Ripa, RS, Jørgensen, E, Hesse, B, Mortensen, S & Kastrup, J 2007, 'Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease', Scandinavian Cardiovascular Journal, vol. 41, no. 6, pp. 397-404. https://doi.org/10.1080/14017430701601651

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abstract = "To investigate the mobilization of non-haematopoietic and haematopoietic cells from the bone marrow induced by intramyocardial VEGF gene therapy and G-CSF treatment alone or in combination in patients with chronic ischemic heart disease (IHD). Secondly, we tested the hypothesis that the quantity of circulating stem cells correlated with improvement in symptoms.",

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AU - Hesse, Birger

AU - Mortensen, Steen

AU - Kastrup, Jens

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KW - Male

KW - Middle Aged

KW - Treatment Outcome

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