Mitochondrial helicases and mitochondrial genome maintenance

Nadja C de Souza-Pinto; Maria Diget Aamann; Tomasz Kulikowicz; Tinna V. Stevnsner; Vilhelm A Bohr

doi:10.1016/j.mad.2010.04.009

Mitochondrial helicases and mitochondrial genome maintenance

Nadja C de Souza-Pinto, Maria Diget Aamann, Tomasz Kulikowicz, Tinna V. Stevnsner, Vilhelm A Bohr

7 Citations (Scopus)

Abstract

Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.

Original language	English
Journal	Mechanisms of Ageing and Development
Volume	131
Issue number	7-8
Pages (from-to)	503-10
Number of pages	8
ISSN	0047-6374
DOIs	https://doi.org/10.1016/j.mad.2010.04.009
Publication status	Published - Jul 2010

Keywords

Age Factors
Aging
Animals
DNA Helicases
DNA, Mitochondrial
Gene Expression Regulation
Humans
Mitochondria

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10.1016/j.mad.2010.04.009

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title = "Mitochondrial helicases and mitochondrial genome maintenance",

abstract = "Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.",

keywords = "Age Factors, Aging, Animals, DNA Helicases, DNA, Mitochondrial, Gene Expression Regulation, Humans, Mitochondria",

author = "{de Souza-Pinto}, {Nadja C} and Aamann, {Maria Diget} and Tomasz Kulikowicz and Stevnsner, {Tinna V.} and Bohr, {Vilhelm A}",

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T1 - Mitochondrial helicases and mitochondrial genome maintenance

AU - de Souza-Pinto, Nadja C

AU - Aamann, Maria Diget

AU - Kulikowicz, Tomasz

AU - Stevnsner, Tinna V.

AU - Bohr, Vilhelm A

PY - 2010/7

Y1 - 2010/7

N2 - Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.

AB - Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.

KW - Age Factors

KW - Aging

KW - Animals

KW - DNA Helicases

KW - DNA, Mitochondrial

KW - Gene Expression Regulation

KW - Humans

KW - Mitochondria

U2 - 10.1016/j.mad.2010.04.009

DO - 10.1016/j.mad.2010.04.009

M3 - Journal article

C2 - 20576512

SN - 0047-6374

VL - 131

SP - 503

EP - 510

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 7-8

ER -

Mitochondrial helicases and mitochondrial genome maintenance

Abstract

Keywords

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