Mitochondrial function in Müller cells - Does it matter?

TY - JOUR

T1 - Mitochondrial function in Müller cells - Does it matter?

AU - Toft-Kehler, Anne Katrine

AU - Skytt, Dorte Marie

AU - Svare, Alicia

AU - Lefevere, Evy

AU - Van Hove, Inge

AU - Moons, Lieve

AU - Waagepetersen, Helle S.

AU - Kolko, Miriam

PY - 2017/9

Y1 - 2017/9

N2 - Growing evidence suggests that mitochondrial dysfunction might play a key role in the pathogenesis of age-related neurodegenerative inner retinal diseases such as diabetic retinopathy and glaucoma. Therefore, the present review provides a perspective on the impact of functional mitochondria in the most predominant glial cells of the retina, the Müller cells. Müller cells span the entire thickness of the neuroretina and are in close proximity to retinal cells including the retinal neurons that provides visual signaling to the brain. Among multiple functions, Müller cells are responsible for the removal of neurotransmitters, buffering potassium, and providing neurons with essential metabolites. Thus, Müller cells are responsible for a stable metabolic dialogue in the inner retina and their crucial role in supporting retinal neurons is indisputable. Müller cell functions require considerable energy production and previous literature has primarily emphasized glycolysis as the main energy provider. However, recent studies highlight the need of mitochondrial ATP production to upheld Müller cell functions. Therefore, the present review aims to provide an overview of the current evidence on the impact of mitochondrial functions in Müller cells.

AB - Growing evidence suggests that mitochondrial dysfunction might play a key role in the pathogenesis of age-related neurodegenerative inner retinal diseases such as diabetic retinopathy and glaucoma. Therefore, the present review provides a perspective on the impact of functional mitochondria in the most predominant glial cells of the retina, the Müller cells. Müller cells span the entire thickness of the neuroretina and are in close proximity to retinal cells including the retinal neurons that provides visual signaling to the brain. Among multiple functions, Müller cells are responsible for the removal of neurotransmitters, buffering potassium, and providing neurons with essential metabolites. Thus, Müller cells are responsible for a stable metabolic dialogue in the inner retina and their crucial role in supporting retinal neurons is indisputable. Müller cell functions require considerable energy production and previous literature has primarily emphasized glycolysis as the main energy provider. However, recent studies highlight the need of mitochondrial ATP production to upheld Müller cell functions. Therefore, the present review aims to provide an overview of the current evidence on the impact of mitochondrial functions in Müller cells.

KW - Mitochondrial dysfunction

KW - Müller cells

KW - Neurodegenerative inner retinal diseases

KW - Retina

U2 - 10.1016/j.mito.2017.02.002

DO - 10.1016/j.mito.2017.02.002

M3 - Journal article

C2 - 28179130

AN - SCOPUS:85014079815

SN - 1567-7249

VL - 36

SP - 43

EP - 51

JO - Mitochondrion

JF - Mitochondrion

ER -