miR-10 in development and cancer

Anders Henrik Lund

doi:10.1038/cdd.2009.58

miR-10 in development and cancer

107 Citations (Scopus)

Abstract

The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire.

Original language	English
Journal	Cell Death and Differentiation
Volume	17
Issue number	2
Pages (from-to)	209-14
Number of pages	5
ISSN	1350-9047
DOIs	https://doi.org/10.1038/cdd.2009.58
Publication status	Published - Feb 2010

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10.1038/cdd.2009.58

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abstract = "The microRNA (miRNA) miR-10 family has attracted attention because of its conservation and the position of the miR-10 genes within the Hox clusters of developmental regulators. In several species, miR-10 is coexpressed with a set of Hox genes and has been found to regulate the translation of Hox transcripts. In addition, members of the miR-10 family are de-regulated in several cancer forms. Aside from acting in translational repression, miR-10 was recently found to bind a group of transcripts containing a terminal oligo-pyrimidine (TOP) motif and to induce their translation, thereby adding a new function to the miRNA repertoire.",

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miR-10 in development and cancer

Abstract

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