Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography

Shabnam Ezzatian-Ahar; Faisal Mohammad Amin; Hayder Ghani Obaid; Nanna Arngrim; Anders Hougaard; Henrik B W Larsson; Messoud Ashina

doi:10.1186/1129-2377-15-27

Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography

Shabnam Ezzatian-Ahar, Faisal Mohammad Amin, Hayder Ghani Obaid, Nanna Arngrim, Anders Hougaard, Henrik B W Larsson, Messoud Ashina

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

BACKGROUND: The circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.

FINDINGS: We found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003.

CONCLUSION: We found no relationship between migraine without aura and incomplete circle of Willis.

Original language	English
Article number	27
Journal	Journal of Headache and Pain
Volume	15
Pages (from-to)	1-4
Number of pages	4
ISSN	1129-2369
DOIs	https://doi.org/10.1186/1129-2377-15-27
Publication status	Published - 1 Dec 2014

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Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography. / Ezzatian-Ahar, Shabnam; Amin, Faisal Mohammad; Obaid, Hayder Ghani et al.
In: Journal of Headache and Pain, Vol. 15, 27, 01.12.2014, p. 1-4.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography",

abstract = "BACKGROUND: The circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.FINDINGS: We found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003.CONCLUSION: We found no relationship between migraine without aura and incomplete circle of Willis.",

author = "Shabnam Ezzatian-Ahar and Amin, {Faisal Mohammad} and Obaid, {Hayder Ghani} and Nanna Arngrim and Anders Hougaard and Larsson, {Henrik B W} and Messoud Ashina",

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doi = "10.1186/1129-2377-15-27",

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T1 - Migraine without aura is not associated with incomplete circle of Willis

T2 - a case–control study using high-resolution magnetic resonance angiography

AU - Ezzatian-Ahar, Shabnam

AU - Amin, Faisal Mohammad

AU - Obaid, Hayder Ghani

AU - Arngrim, Nanna

AU - Hougaard, Anders

AU - Larsson, Henrik B W

AU - Ashina, Messoud

PY - 2014/12/1

Y1 - 2014/12/1

N2 - BACKGROUND: The circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.FINDINGS: We found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003.CONCLUSION: We found no relationship between migraine without aura and incomplete circle of Willis.

AB - BACKGROUND: The circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.FINDINGS: We found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003.CONCLUSION: We found no relationship between migraine without aura and incomplete circle of Willis.

U2 - 10.1186/1129-2377-15-27

DO - 10.1186/1129-2377-15-27

M3 - Journal article

C2 - 24886373

SN - 1129-2369

VL - 15

SP - 1

EP - 4

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

M1 - 27

ER -

Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography

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