MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?

TY - JOUR

T1 - MicroRNAs

T2 - new biomarkers and therapeutic targets after cardiac arrest?

AU - Devaux, Yvan

AU - Stammet, Pascal

AU - Friberg, Hans

AU - Hassager, Christian

AU - Kuiper, Michael A

AU - Wise, Matt P

AU - Nielsen, Niklas

AU - Biomarker subcommittee of TTM trial (Target Temperature Management After Cardiac Arrest, NCT01020916)

PY - 2015/2/11

Y1 - 2015/2/11

N2 - Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest.

AB - Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest.

KW - Biomarkers

KW - Cardiopulmonary Resuscitation

KW - Critical Care

KW - Heart Arrest

KW - Humans

KW - Hypothermia, Induced

KW - MicroRNAs

KW - Prognosis

U2 - 10.1186/s13054-015-0767-2

DO - 10.1186/s13054-015-0767-2

M3 - Review

C2 - 25886727

SN - 1364-8535

VL - 19

SP - 1

EP - 8

JO - Critical Care

JF - Critical Care

IS - 54

M1 - 54

ER -