MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed

Torben Wilde Schou; R. Labouriau; A. Permin; Jens Peter Christensen; P. Sørensen; H.P. Cu; V.K. Nguyen; H.R. Juul-Madsen

doi:10.1016/j.vetimm.2009.10.030

MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed

Torben Wilde Schou, R. Labouriau, A. Permin, Jens Peter Christensen, P. Sørensen, H.P. Cu, V.K. Nguyen, H.R. Juul-Madsen

27 Citations (Scopus)

Abstract

In three independent experimental infection studies, the susceptibility and course of infection of three pathogens considered of importance in most poultry production systems, Ascaridia galli, Salmonella Enteritidis and Pasteurella multocida were compared in two chicken breeds, the indigenous Vietnamese Ri and the commercial Luong Phuong. Furthermore, the association of the Major Histocompatibility Complex (MHC) with disease-related parameters was evaluated, using alleles of the LEI0258 microsatellite as markers for MHC haplotypes.The Ri chickens were found to be more resistant to A. galli and S. Enteritidis than commercial Luong Phuong chickens. In contrast, the Ri chickens were more susceptible to P. multocida, although production parameters were more affected in the Luong Phuong chickens. Furthermore, it was shown that the individual variations observed in response to the infections were influenced by the MHC. Using marker alleles of the microsatellite LEI0258, which is located within the MHC region, several MHC haplotypes were identified as being associated with infection intensity of A. galli. An association of the MHC with the specific antibody response to S. Enteritidis was also found where four MHC haplotypes were shown to be associated with high specific antibody response. Finally, one MHC haplotype was identified as being associated with pathological lesions and mortality in the P. multocida experiment. Although not statistically significant, our analysis suggested that this haplotype might be associated with resistance. These results demonstrate the presence of local genetic resources in Vietnamese chickens, which could be utilized in breeding programmes aiming at improving disease resistance.

Original language	English
Journal	Veterinary Immunology and Immunopathology
Volume	135
Issue number	1-2
Pages (from-to)	52-63
Number of pages	12
ISSN	0165-2427
DOIs	https://doi.org/10.1016/j.vetimm.2009.10.030
Publication status	Published - May 2010

Keywords

Former LIFE faculty
major histocompatibility complex
MHC
disease resistance
chickens
indigenous
exotic
vietnam
Ascaridia galli
Salmonella Enteriditis
Pasteurella multocida

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10.1016/j.vetimm.2009.10.030

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Schou, T. W., Labouriau, R., Permin, A., Christensen, J. P., Sørensen, P., Cu, H. P., Nguyen, V. K., & Juul-Madsen, H. R. (2010). MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed. Veterinary Immunology and Immunopathology, 135(1-2), 52-63. https://doi.org/10.1016/j.vetimm.2009.10.030

MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed. / Schou, Torben Wilde; Labouriau, R.; Permin, A. et al.
In: Veterinary Immunology and Immunopathology, Vol. 135, No. 1-2, 05.2010, p. 52-63.

Research output: Contribution to journal › Journal article › Research › peer-review

Schou, TW, Labouriau, R, Permin, A, Christensen, JP, Sørensen, P, Cu, HP, Nguyen, VK & Juul-Madsen, HR 2010, 'MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed', Veterinary Immunology and Immunopathology, vol. 135, no. 1-2, pp. 52-63. https://doi.org/10.1016/j.vetimm.2009.10.030

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title = "MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed",

abstract = "In three independent experimental infection studies, the susceptibility and course of infection of three pathogens considered of importance in most poultry production systems, Ascaridia galli, Salmonella Enteritidis and Pasteurella multocida were compared in two chicken breeds, the indigenous Vietnamese Ri and the commercial Luong Phuong. Furthermore, the association of the Major Histocompatibility Complex (MHC) with disease-related parameters was evaluated, using alleles of the LEI0258 microsatellite as markers for MHC haplotypes.The Ri chickens were found to be more resistant to A. galli and S. Enteritidis than commercial Luong Phuong chickens. In contrast, the Ri chickens were more susceptible to P. multocida, although production parameters were more affected in the Luong Phuong chickens. Furthermore, it was shown that the individual variations observed in response to the infections were influenced by the MHC. Using marker alleles of the microsatellite LEI0258, which is located within the MHC region, several MHC haplotypes were identified as being associated with infection intensity of A. galli. An association of the MHC with the specific antibody response to S. Enteritidis was also found where four MHC haplotypes were shown to be associated with high specific antibody response. Finally, one MHC haplotype was identified as being associated with pathological lesions and mortality in the P. multocida experiment. Although not statistically significant, our analysis suggested that this haplotype might be associated with resistance. These results demonstrate the presence of local genetic resources in Vietnamese chickens, which could be utilized in breeding programmes aiming at improving disease resistance.",

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author = "Schou, {Torben Wilde} and R. Labouriau and A. Permin and Christensen, {Jens Peter} and P. S{\o}rensen and H.P. Cu and V.K. Nguyen and H.R. Juul-Madsen",

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doi = "10.1016/j.vetimm.2009.10.030",

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T1 - MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed

AU - Schou, Torben Wilde

AU - Labouriau, R.

AU - Permin, A.

AU - Christensen, Jens Peter

AU - Sørensen, P.

AU - Cu, H.P.

AU - Nguyen, V.K.

AU - Juul-Madsen, H.R.

PY - 2010/5

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N2 - In three independent experimental infection studies, the susceptibility and course of infection of three pathogens considered of importance in most poultry production systems, Ascaridia galli, Salmonella Enteritidis and Pasteurella multocida were compared in two chicken breeds, the indigenous Vietnamese Ri and the commercial Luong Phuong. Furthermore, the association of the Major Histocompatibility Complex (MHC) with disease-related parameters was evaluated, using alleles of the LEI0258 microsatellite as markers for MHC haplotypes.The Ri chickens were found to be more resistant to A. galli and S. Enteritidis than commercial Luong Phuong chickens. In contrast, the Ri chickens were more susceptible to P. multocida, although production parameters were more affected in the Luong Phuong chickens. Furthermore, it was shown that the individual variations observed in response to the infections were influenced by the MHC. Using marker alleles of the microsatellite LEI0258, which is located within the MHC region, several MHC haplotypes were identified as being associated with infection intensity of A. galli. An association of the MHC with the specific antibody response to S. Enteritidis was also found where four MHC haplotypes were shown to be associated with high specific antibody response. Finally, one MHC haplotype was identified as being associated with pathological lesions and mortality in the P. multocida experiment. Although not statistically significant, our analysis suggested that this haplotype might be associated with resistance. These results demonstrate the presence of local genetic resources in Vietnamese chickens, which could be utilized in breeding programmes aiming at improving disease resistance.

AB - In three independent experimental infection studies, the susceptibility and course of infection of three pathogens considered of importance in most poultry production systems, Ascaridia galli, Salmonella Enteritidis and Pasteurella multocida were compared in two chicken breeds, the indigenous Vietnamese Ri and the commercial Luong Phuong. Furthermore, the association of the Major Histocompatibility Complex (MHC) with disease-related parameters was evaluated, using alleles of the LEI0258 microsatellite as markers for MHC haplotypes.The Ri chickens were found to be more resistant to A. galli and S. Enteritidis than commercial Luong Phuong chickens. In contrast, the Ri chickens were more susceptible to P. multocida, although production parameters were more affected in the Luong Phuong chickens. Furthermore, it was shown that the individual variations observed in response to the infections were influenced by the MHC. Using marker alleles of the microsatellite LEI0258, which is located within the MHC region, several MHC haplotypes were identified as being associated with infection intensity of A. galli. An association of the MHC with the specific antibody response to S. Enteritidis was also found where four MHC haplotypes were shown to be associated with high specific antibody response. Finally, one MHC haplotype was identified as being associated with pathological lesions and mortality in the P. multocida experiment. Although not statistically significant, our analysis suggested that this haplotype might be associated with resistance. These results demonstrate the presence of local genetic resources in Vietnamese chickens, which could be utilized in breeding programmes aiming at improving disease resistance.

KW - Former LIFE faculty

KW - vietnam

KW - major histocompatibility complex

KW - MHC

KW - disease resistance

KW - chickens

KW - indigenous

KW - exotic

KW - vietnam

KW - Ascaridia galli

KW - Salmonella Enteriditis

KW - Pasteurella multocida

U2 - 10.1016/j.vetimm.2009.10.030

DO - 10.1016/j.vetimm.2009.10.030

M3 - Journal article

SN - 0165-2427

VL - 135

SP - 52

EP - 63

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 1-2

ER -

MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed

Abstract

Keywords

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