Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries

TY - JOUR

T1 - Methylisothiazolinone and benzisothiazolinone are widely used in paint

T2 - a multicentre study of paints from five European countries

AU - Schwensen, Jakob F

AU - Lundov, Michael Dyrgaard

AU - Bossi, Rossana

AU - Banerjee, Piu

AU - Giménez-Arnau, Elena

AU - Lepoittevin, Jean-Pierre

AU - Lidén, Carola

AU - Uter, Wolfgang

AU - Yazar, Kerem

AU - White, Ian R

AU - Johansen, Jeanne D

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Summary Background In view of the current epidemic of contact allergy to methylisothiazolinone (MI), it is important to clarify the extent of use of MI and related isothiazolinones in paints currently available for the consumer and worker in Europe. Objectives To elucidate the use and concentrations of MI, methylchloroisothiazolinone (MCI) and benzisothiazolinone (BIT) in paints on the European retail market. Methods Wall paints (n=71) were randomly purchased in retail outlets in five European countries. The paints were quantitatively analysed for their contents of MI, MCI and BIT by high-performance liquid chromatography coupled to tandem mass spectrometry. Results MI was found in 93.0% (n=66) of the paints, with concentrations ranging from 0.7 to 180.9ppm, MCI in 23.9% (n=17), ranging from 0.26 to 11.4ppm, and BIT in 95.8% (n=68), ranging from 0.1 to 462.5ppm. High concentrations of MI were found in paints from all five countries. Paints purchased in Denmark and Sweden contained especially high concentrations of BIT. Conclusion The use of MI across European countries is extensive. In view of the ongoing epidemic of MI contact allergy, an evaluation of the safety of MI in paints is needed.

AB - Summary Background In view of the current epidemic of contact allergy to methylisothiazolinone (MI), it is important to clarify the extent of use of MI and related isothiazolinones in paints currently available for the consumer and worker in Europe. Objectives To elucidate the use and concentrations of MI, methylchloroisothiazolinone (MCI) and benzisothiazolinone (BIT) in paints on the European retail market. Methods Wall paints (n=71) were randomly purchased in retail outlets in five European countries. The paints were quantitatively analysed for their contents of MI, MCI and BIT by high-performance liquid chromatography coupled to tandem mass spectrometry. Results MI was found in 93.0% (n=66) of the paints, with concentrations ranging from 0.7 to 180.9ppm, MCI in 23.9% (n=17), ranging from 0.26 to 11.4ppm, and BIT in 95.8% (n=68), ranging from 0.1 to 462.5ppm. High concentrations of MI were found in paints from all five countries. Paints purchased in Denmark and Sweden contained especially high concentrations of BIT. Conclusion The use of MI across European countries is extensive. In view of the ongoing epidemic of MI contact allergy, an evaluation of the safety of MI in paints is needed.

KW - Dermatitis, Allergic Contact

KW - Dermatitis, Occupational

KW - Disinfectants

KW - Europe

KW - Humans

KW - Paint

KW - Thiazoles

U2 - 10.1111/cod.12322

DO - 10.1111/cod.12322

M3 - Journal article

C2 - 25510184

SN - 0105-1873

VL - 72

SP - 127

EP - 138

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 3

ER -