Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting

Line Raaby; Claus Zachariae; Monika Østensen; Lene Heickendorff; Peter Thielsen; Henning Grønbæk; Lone Skov; Nini Kyvsgaard; Jakob T Madsen; Michael Heidenheim; Anne T Funding; Gitte Strauss; Rune Lindberg; Lars Iversen

doi:10.2340/00015555-2599

Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting

Line Raaby, Claus Zachariae, Monika Østensen, Lene Heickendorff, Peter Thielsen, Henning Grønbæk, Lone Skov, Nini Kyvsgaard, Jakob T Madsen, Michael Heidenheim, Anne T Funding, Gitte Strauss, Rune Lindberg, Lars Iversen

Department of Clinical Medicine

25 Citations (Scopus)

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Abstract

Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Health and Care Excellence (NICE) guideline, it is important to discuss and adjust these guidelines to national standards. An expert meeting was held in Denmark at the end of 2014, in order to reach consensus regarding the use of MTX in dermatological practice in Denmark. Participants included dermatologists, hepatologists, paediatricians, clinical biochemists and a rheumatologist. Topics discussed were: liver disease monitoring, teratogenic effects of MTX, risk of cancer, and use of MTX in children. We report here the conclusions of this expert meeting regarding use of MTX in dermatological practice.

Original language	English
Journal	Acta Dermatovenereologica
Volume	97
Issue number	4
Pages (from-to)	426-432
ISSN	0001-5555
DOIs	https://doi.org/10.2340/00015555-2599
Publication status	Published - 2017

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Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert MeetingFinal published version, 668 KBLicence: CC BY-NC

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Raaby, L., Zachariae, C., Østensen, M., Heickendorff, L., Thielsen, P., Grønbæk, H., Skov, L., Kyvsgaard, N., Madsen, J. T., Heidenheim, M., Funding, A. T., Strauss, G., Lindberg, R., & Iversen, L. (2017). Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting. Acta Dermatovenereologica, 97(4), 426-432. https://doi.org/10.2340/00015555-2599

Raaby, L, Zachariae, C, Østensen, M, Heickendorff, L, Thielsen, P, Grønbæk, H, Skov, L, Kyvsgaard, N, Madsen, JT, Heidenheim, M, Funding, AT, Strauss, G, Lindberg, R & Iversen, L 2017, 'Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting', Acta Dermatovenereologica, vol. 97, no. 4, pp. 426-432. https://doi.org/10.2340/00015555-2599

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abstract = "Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Health and Care Excellence (NICE) guideline, it is important to discuss and adjust these guidelines to national standards. An expert meeting was held in Denmark at the end of 2014, in order to reach consensus regarding the use of MTX in dermatological practice in Denmark. Participants included dermatologists, hepatologists, paediatricians, clinical biochemists and a rheumatologist. Topics discussed were: liver disease monitoring, teratogenic effects of MTX, risk of cancer, and use of MTX in children. We report here the conclusions of this expert meeting regarding use of MTX in dermatological practice.",

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AU - Thielsen, Peter

AU - Grønbæk, Henning

AU - Skov, Lone

AU - Kyvsgaard, Nini

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AB - Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Health and Care Excellence (NICE) guideline, it is important to discuss and adjust these guidelines to national standards. An expert meeting was held in Denmark at the end of 2014, in order to reach consensus regarding the use of MTX in dermatological practice in Denmark. Participants included dermatologists, hepatologists, paediatricians, clinical biochemists and a rheumatologist. Topics discussed were: liver disease monitoring, teratogenic effects of MTX, risk of cancer, and use of MTX in children. We report here the conclusions of this expert meeting regarding use of MTX in dermatological practice.

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JF - Acta Dermato-Venereologica

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ER -

Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting

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