Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Patrick Van Dijck; Jelmer Sjollema; Bruno P Cammue; Katrien Lagrou; Judith Berman; Christophe d'Enfert; David R Andes; Maiken C. Arendrup; Axel A Brakhage; Richard Calderone; Emilia Cantón; Tom Coenye; Paul Cos; Leah E Cowen; Mira Edgerton; Ana Espinel-Ingroff; Scott G Filler; Mahmoud Ghannoum; Neil A R Gow; Hubertus Haas; Mary Ann Jabra-Rizk; Elizabeth M Johnson; Shawn R Lockhart; Jose L Lopez-Ribot; Johan Maertens; Carol A Munro; Jeniel E Nett; Clarissa J Nobile; Michael A Pfaller; Gordon Ramage; Dominique Sanglard; Maurizio Sanguinetti; Isabel Spriet; Paul E Verweij; Adilia Warris; Joost Wauters; Michael R Yeaman; Sebastian A J Zaat; Karin Thevissen

doi:10.15698/mic2018.07.638

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Patrick Van Dijck, Jelmer Sjollema, Bruno P Cammue, Katrien Lagrou, Judith Berman, Christophe d'Enfert, David R Andes, Maiken C. Arendrup, Axel A Brakhage, Richard Calderone, Emilia Cantón, Tom Coenye, Paul Cos, Leah E Cowen, Mira Edgerton, Ana Espinel-Ingroff, Scott G Filler, Mahmoud Ghannoum, Neil A R Gow, Hubertus HaasMary Ann Jabra-Rizk, Elizabeth M Johnson, Shawn R Lockhart, Jose L Lopez-Ribot, Johan Maertens, Carol A Munro, Jeniel E Nett, Clarissa J Nobile, Michael A Pfaller, Gordon Ramage, Dominique Sanglard, Maurizio Sanguinetti, Isabel Spriet, Paul E Verweij, Adilia Warris, Joost Wauters, Michael R Yeaman, Sebastian A J Zaat, Karin Thevissen

Department of Clinical Medicine

33 Citations (Scopus)

36 Downloads (Pure)

Abstract

Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

Original language	English
Journal	Microbial Cell Factories
Volume	5
Issue number	7
Pages (from-to)	300-326
Number of pages	27
ISSN	2311-2638
DOIs	https://doi.org/10.15698/mic2018.07.638
Publication status	Published - Jul 2018

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10.15698/mic2018.07.638

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilmsFinal published version, 928 KB

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Van Dijck, P., Sjollema, J., Cammue, B. P., Lagrou, K., Berman, J., d'Enfert, C., Andes, D. R., Arendrup, M. C., Brakhage, A. A., Calderone, R., Cantón, E., Coenye, T., Cos, P., Cowen, L. E., Edgerton, M., Espinel-Ingroff, A., Filler, S. G., Ghannoum, M., Gow, N. A. R., ... Thevissen, K. (2018). Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microbial Cell Factories, 5(7), 300-326. https://doi.org/10.15698/mic2018.07.638

Van Dijck, P, Sjollema, J, Cammue, BP, Lagrou, K, Berman, J, d'Enfert, C, Andes, DR, Arendrup, MC, Brakhage, AA, Calderone, R, Cantón, E, Coenye, T, Cos, P, Cowen, LE, Edgerton, M, Espinel-Ingroff, A, Filler, SG, Ghannoum, M, Gow, NAR, Haas, H, Jabra-Rizk, MA, Johnson, EM, Lockhart, SR, Lopez-Ribot, JL, Maertens, J, Munro, CA, Nett, JE, Nobile, CJ, Pfaller, MA, Ramage, G, Sanglard, D, Sanguinetti, M, Spriet, I, Verweij, PE, Warris, A, Wauters, J, Yeaman, MR, Zaat, SAJ & Thevissen, K 2018, 'Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms', Microbial Cell Factories, vol. 5, no. 7, pp. 300-326. https://doi.org/10.15698/mic2018.07.638

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abstract = "Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.",

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AU - Van Dijck, Patrick

AU - Sjollema, Jelmer

AU - Cammue, Bruno P

AU - Lagrou, Katrien

AU - Berman, Judith

AU - d'Enfert, Christophe

AU - Andes, David R

AU - Arendrup, Maiken C.

AU - Brakhage, Axel A

AU - Calderone, Richard

AU - Cantón, Emilia

AU - Coenye, Tom

AU - Cos, Paul

AU - Cowen, Leah E

AU - Edgerton, Mira

AU - Espinel-Ingroff, Ana

AU - Filler, Scott G

AU - Ghannoum, Mahmoud

AU - Gow, Neil A R

AU - Haas, Hubertus

AU - Jabra-Rizk, Mary Ann

AU - Johnson, Elizabeth M

AU - Lockhart, Shawn R

AU - Lopez-Ribot, Jose L

AU - Maertens, Johan

AU - Munro, Carol A

AU - Nett, Jeniel E

AU - Nobile, Clarissa J

AU - Pfaller, Michael A

AU - Ramage, Gordon

AU - Sanglard, Dominique

AU - Sanguinetti, Maurizio

AU - Spriet, Isabel

AU - Verweij, Paul E

AU - Warris, Adilia

AU - Wauters, Joost

AU - Yeaman, Michael R

AU - Zaat, Sebastian A J

AU - Thevissen, Karin

PY - 2018/7

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N2 - Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

AB - Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

U2 - 10.15698/mic2018.07.638

DO - 10.15698/mic2018.07.638

M3 - Review

C2 - 29992128

SN - 1475-2859

VL - 5

SP - 300

EP - 326

JO - Microbial Cell

JF - Microbial Cell

IS - 7

ER -

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Abstract

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