TY - JOUR
T1 - Metabolism of selenite to selenosugar and trimethylselenonium in vivo
T2 - tissue dependency and requirement for S-adenosylmethionine-dependent methylation
AU - Jackson, Matthew I
AU - Lunøe, Kristoffer
AU - Gabel-Jensen, Charlotte
AU - Gammelgaard, Bente
AU - Combs, Gerald F
N1 - © 2013.
PY - 2013/12
Y1 - 2013/12
N2 - Impaired S-adenosylmethionine (SAM)-dependent transmethylation and methylation capacity feature in diseases related to obesity or aging, and selenium (Se) metabolism is altered in these states. We tested the hypothesis that SAM metabolism is required for methylation and excretion of Se in a rat model. Four hours after selenite and periodate-oxidized adenosine (POA; an inhibitor of SAM metabolism) were administered, circulating markers of single-carbon status were unchanged, except for decreased circulating phosphatidylcholine (P
AB - Impaired S-adenosylmethionine (SAM)-dependent transmethylation and methylation capacity feature in diseases related to obesity or aging, and selenium (Se) metabolism is altered in these states. We tested the hypothesis that SAM metabolism is required for methylation and excretion of Se in a rat model. Four hours after selenite and periodate-oxidized adenosine (POA; an inhibitor of SAM metabolism) were administered, circulating markers of single-carbon status were unchanged, except for decreased circulating phosphatidylcholine (P
U2 - 10.1016/j.jnutbio.2013.04.007
DO - 10.1016/j.jnutbio.2013.04.007
M3 - Journal article
C2 - 24139672
SN - 0955-2863
VL - 24
SP - 2023
EP - 2030
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
IS - 12
ER -
