Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

Iben Marie Miller; Christina Ellervik; Shiva Yazdanyar; Gregor B E Jemec

doi:10.1016/j.jaad.2013.06.053

Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

Iben Marie Miller, Christina Ellervik, Shiva Yazdanyar, Gregor B E Jemec

171 Citations (Scopus)

Abstract

BACKGROUND: The possible connection between psoriasis with cardiovascular disease and associated risk factors has been implied, but inconsistent results have been reported.

OBJECTIVE: We sought to create an overview and statistical summary of the previous literature with elucidating subgroup analysis.

METHODS: This was a meta-analysis of observational studies using random effect statistics. A systematic search of observational studies of psoriasis as study variable and cardiovascular disease and associated risk factors as outcome, published before October 25, 2012, was conducted.

RESULTS: Of 835 references in the original search, 75 relevant articles were identified. We included 503,686 cases and 29,686,694 controls. Psoriasis was associated with cardiovascular disease in total (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2-1.7), ischemic heart disease (OR 1.5; 95% CI 1.2-1.9), peripheral vascular disease (OR 1.5; 95% CI 1.2-1.8), atherosclerosis (OR 1.1; 95% CI 1.1-1.2), diabetes (OR 1.9; 95% CI 1.5-2.5), hypertension (OR 1.8; 95% CI 1.6-2.0), dyslipidemia (OR 1.5; 95% CI 1.4-1.7), obesity by body mass index (OR 1.8; 95% CI 1.4-2.2), obesity by abdominal fat (OR 1.6; 95% CI 1.2-2.3), and the metabolic syndrome (OR 1.8; 95% CI 1.2-2.8), but not associated with cerebrovascular disease (OR 1.1; 95% CI 0.9-1.3) and cardiovascular mortality (OR 0.9; 95% CI 0.4-2.2). The strongest associations were seen in hospital-based studies and psoriatic arthritis. Population-based studies did not show significant associations, with the exception of dyslipidemia.

LIMITATIONS: The heterogeneity of the studies makes clinical interpretation challenging.

CONCLUSIONS: In aggregate, psoriasis was associated with ischemic heart disease and cardiovascular risk factors. The association was only significant for hospital-based studies, except for dyslipidemia, which was also significant in population-based studies.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	69
Issue number	6
Pages (from-to)	1014-24
Number of pages	11
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2013.06.053
Publication status	Published - Dec 2013

Keywords

Cardiovascular Diseases
Humans
Observational Study as Topic
Psoriasis
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaad.2013.06.053

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title = "Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors",

abstract = "BACKGROUND: The possible connection between psoriasis with cardiovascular disease and associated risk factors has been implied, but inconsistent results have been reported.OBJECTIVE: We sought to create an overview and statistical summary of the previous literature with elucidating subgroup analysis.METHODS: This was a meta-analysis of observational studies using random effect statistics. A systematic search of observational studies of psoriasis as study variable and cardiovascular disease and associated risk factors as outcome, published before October 25, 2012, was conducted.RESULTS: Of 835 references in the original search, 75 relevant articles were identified. We included 503,686 cases and 29,686,694 controls. Psoriasis was associated with cardiovascular disease in total (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2-1.7), ischemic heart disease (OR 1.5; 95% CI 1.2-1.9), peripheral vascular disease (OR 1.5; 95% CI 1.2-1.8), atherosclerosis (OR 1.1; 95% CI 1.1-1.2), diabetes (OR 1.9; 95% CI 1.5-2.5), hypertension (OR 1.8; 95% CI 1.6-2.0), dyslipidemia (OR 1.5; 95% CI 1.4-1.7), obesity by body mass index (OR 1.8; 95% CI 1.4-2.2), obesity by abdominal fat (OR 1.6; 95% CI 1.2-2.3), and the metabolic syndrome (OR 1.8; 95% CI 1.2-2.8), but not associated with cerebrovascular disease (OR 1.1; 95% CI 0.9-1.3) and cardiovascular mortality (OR 0.9; 95% CI 0.4-2.2). The strongest associations were seen in hospital-based studies and psoriatic arthritis. Population-based studies did not show significant associations, with the exception of dyslipidemia.LIMITATIONS: The heterogeneity of the studies makes clinical interpretation challenging.CONCLUSIONS: In aggregate, psoriasis was associated with ischemic heart disease and cardiovascular risk factors. The association was only significant for hospital-based studies, except for dyslipidemia, which was also significant in population-based studies.",

keywords = "Cardiovascular Diseases, Humans, Observational Study as Topic, Psoriasis, Risk Factors",

author = "Miller, {Iben Marie} and Christina Ellervik and Shiva Yazdanyar and Jemec, {Gregor B E}",

year = "2013",

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doi = "10.1016/j.jaad.2013.06.053",

language = "English",

volume = "69",

pages = "1014--24",

journal = "American Academy of Dermatology. Journal",

issn = "0190-9622",

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T1 - Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

AU - Miller, Iben Marie

AU - Ellervik, Christina

AU - Yazdanyar, Shiva

AU - Jemec, Gregor B E

PY - 2013/12

Y1 - 2013/12

N2 - BACKGROUND: The possible connection between psoriasis with cardiovascular disease and associated risk factors has been implied, but inconsistent results have been reported.OBJECTIVE: We sought to create an overview and statistical summary of the previous literature with elucidating subgroup analysis.METHODS: This was a meta-analysis of observational studies using random effect statistics. A systematic search of observational studies of psoriasis as study variable and cardiovascular disease and associated risk factors as outcome, published before October 25, 2012, was conducted.RESULTS: Of 835 references in the original search, 75 relevant articles were identified. We included 503,686 cases and 29,686,694 controls. Psoriasis was associated with cardiovascular disease in total (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2-1.7), ischemic heart disease (OR 1.5; 95% CI 1.2-1.9), peripheral vascular disease (OR 1.5; 95% CI 1.2-1.8), atherosclerosis (OR 1.1; 95% CI 1.1-1.2), diabetes (OR 1.9; 95% CI 1.5-2.5), hypertension (OR 1.8; 95% CI 1.6-2.0), dyslipidemia (OR 1.5; 95% CI 1.4-1.7), obesity by body mass index (OR 1.8; 95% CI 1.4-2.2), obesity by abdominal fat (OR 1.6; 95% CI 1.2-2.3), and the metabolic syndrome (OR 1.8; 95% CI 1.2-2.8), but not associated with cerebrovascular disease (OR 1.1; 95% CI 0.9-1.3) and cardiovascular mortality (OR 0.9; 95% CI 0.4-2.2). The strongest associations were seen in hospital-based studies and psoriatic arthritis. Population-based studies did not show significant associations, with the exception of dyslipidemia.LIMITATIONS: The heterogeneity of the studies makes clinical interpretation challenging.CONCLUSIONS: In aggregate, psoriasis was associated with ischemic heart disease and cardiovascular risk factors. The association was only significant for hospital-based studies, except for dyslipidemia, which was also significant in population-based studies.

AB - BACKGROUND: The possible connection between psoriasis with cardiovascular disease and associated risk factors has been implied, but inconsistent results have been reported.OBJECTIVE: We sought to create an overview and statistical summary of the previous literature with elucidating subgroup analysis.METHODS: This was a meta-analysis of observational studies using random effect statistics. A systematic search of observational studies of psoriasis as study variable and cardiovascular disease and associated risk factors as outcome, published before October 25, 2012, was conducted.RESULTS: Of 835 references in the original search, 75 relevant articles were identified. We included 503,686 cases and 29,686,694 controls. Psoriasis was associated with cardiovascular disease in total (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.2-1.7), ischemic heart disease (OR 1.5; 95% CI 1.2-1.9), peripheral vascular disease (OR 1.5; 95% CI 1.2-1.8), atherosclerosis (OR 1.1; 95% CI 1.1-1.2), diabetes (OR 1.9; 95% CI 1.5-2.5), hypertension (OR 1.8; 95% CI 1.6-2.0), dyslipidemia (OR 1.5; 95% CI 1.4-1.7), obesity by body mass index (OR 1.8; 95% CI 1.4-2.2), obesity by abdominal fat (OR 1.6; 95% CI 1.2-2.3), and the metabolic syndrome (OR 1.8; 95% CI 1.2-2.8), but not associated with cerebrovascular disease (OR 1.1; 95% CI 0.9-1.3) and cardiovascular mortality (OR 0.9; 95% CI 0.4-2.2). The strongest associations were seen in hospital-based studies and psoriatic arthritis. Population-based studies did not show significant associations, with the exception of dyslipidemia.LIMITATIONS: The heterogeneity of the studies makes clinical interpretation challenging.CONCLUSIONS: In aggregate, psoriasis was associated with ischemic heart disease and cardiovascular risk factors. The association was only significant for hospital-based studies, except for dyslipidemia, which was also significant in population-based studies.

KW - Cardiovascular Diseases

KW - Humans

KW - Observational Study as Topic

KW - Psoriasis

KW - Risk Factors

U2 - 10.1016/j.jaad.2013.06.053

DO - 10.1016/j.jaad.2013.06.053

M3 - Journal article

C2 - 24238156

SN - 0190-9622

VL - 69

SP - 1014

EP - 1024

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

IS - 6

ER -

Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

Abstract

Keywords

UN SDGs

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