Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

Babette L R Reijs; Inez H G B Ramakers; Sebastian Köhler; Charlotte E Teunissen; Marleen Koel-Simmelink; Pradeep J Nathan; Magda Tsolaki; Lars-Olof Wahlund; Gunhild Waldemar; Lucrezia Hausner; Rik Vandenberghe; Peter Johannsen; Andrew Blackwell; Hugo Vanderstichele; Frans Verhey; Pieter Jelle Visser

doi:10.3233/JAD-160766

Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

Babette L R Reijs, Inez H G B Ramakers, Sebastian Köhler, Charlotte E Teunissen, Marleen Koel-Simmelink, Pradeep J Nathan, Magda Tsolaki, Lars-Olof Wahlund, Gunhild Waldemar, Lucrezia Hausner, Rik Vandenberghe, Peter Johannsen, Andrew Blackwell, Hugo Vanderstichele, Frans Verhey, Pieter Jelle Visser

Department of Clinical Medicine

15 Citations (Scopus)

Abstract

Background: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression. Objective: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline. Methods: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline. Results: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis. Conclusion: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

Original language	English
Journal	Journal of Alzheimer's Disease
Volume	60
Issue number	3
Pages (from-to)	1119-1128
Number of pages	10
ISSN	1387-2877
DOIs	https://doi.org/10.3233/JAD-160766
Publication status	Published - 2017

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Journal Article

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10.3233/JAD-160766

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Reijs, B. L. R., Ramakers, I. H. G. B., Köhler, S., Teunissen, C. E., Koel-Simmelink, M., Nathan, P. J., Tsolaki, M., Wahlund, L.-O., Waldemar, G., Hausner, L., Vandenberghe, R., Johannsen, P., Blackwell, A., Vanderstichele, H., Verhey, F., & Visser, P. J. (2017). Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study. Journal of Alzheimer's Disease, 60(3), 1119-1128. https://doi.org/10.3233/JAD-160766

Reijs, BLR, Ramakers, IHGB, Köhler, S, Teunissen, CE, Koel-Simmelink, M, Nathan, PJ, Tsolaki, M, Wahlund, L-O, Waldemar, G, Hausner, L, Vandenberghe, R, Johannsen, P, Blackwell, A, Vanderstichele, H, Verhey, F & Visser, PJ 2017, 'Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study', Journal of Alzheimer's Disease, vol. 60, no. 3, pp. 1119-1128. https://doi.org/10.3233/JAD-160766

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title = "Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study",

abstract = "Background: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression. Objective: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline. Methods: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline. Results: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis. Conclusion: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.",

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author = "Reijs, {Babette L R} and Ramakers, {Inez H G B} and Sebastian K{\"o}hler and Teunissen, {Charlotte E} and Marleen Koel-Simmelink and Nathan, {Pradeep J} and Magda Tsolaki and Lars-Olof Wahlund and Gunhild Waldemar and Lucrezia Hausner and Rik Vandenberghe and Peter Johannsen and Andrew Blackwell and Hugo Vanderstichele and Frans Verhey and Visser, {Pieter Jelle}",

year = "2017",

doi = "10.3233/JAD-160766",

language = "English",

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TY - JOUR

T1 - Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers

T2 - A Longitudinal Cohort Study

AU - Reijs, Babette L R

AU - Ramakers, Inez H G B

AU - Köhler, Sebastian

AU - Teunissen, Charlotte E

AU - Koel-Simmelink, Marleen

AU - Nathan, Pradeep J

AU - Tsolaki, Magda

AU - Wahlund, Lars-Olof

AU - Waldemar, Gunhild

AU - Hausner, Lucrezia

AU - Vandenberghe, Rik

AU - Johannsen, Peter

AU - Blackwell, Andrew

AU - Vanderstichele, Hugo

AU - Verhey, Frans

AU - Visser, Pieter Jelle

PY - 2017

Y1 - 2017

N2 - Background: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression. Objective: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline. Methods: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline. Results: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis. Conclusion: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

AB - Background: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression. Objective: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline. Methods: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline. Results: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis. Conclusion: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline.

KW - Journal Article

U2 - 10.3233/JAD-160766

DO - 10.3233/JAD-160766

M3 - Journal article

C2 - 28984585

SN - 1387-2877

VL - 60

SP - 1119

EP - 1128

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 3

ER -

Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study

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