Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis

Irena Hainerová; Lesli H Larsen; Birgitte Holst; Marie Finková; Vojtech Hainer; Jan Lebl; Torben Hansen; Oluf Pedersen

doi:10.1210/jc.2007-0352

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis

Irena Hainerová, Lesli H Larsen, Birgitte Holst, Marie Finková, Vojtech Hainer, Jan Lebl, Torben Hansen, Oluf Pedersen

63 Citations (Scopus)

Abstract

Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common known cause of monogenic human obesity.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	92
Issue number	9
Pages (from-to)	3689-96
Number of pages	8
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2007-0352
Publication status	Published - 2007

Keywords

Adolescent
Adult
Body Height
Body Weight
Case-Control Studies
Child
Child, Preschool
Czech Republic
DNA Mutational Analysis
Female
Follow-Up Studies
Gene Frequency
Humans
Male
Models, Biological
Mutation
Obesity
Pedigree
Phenotype
Receptor, Melanocortin, Type 4
Weight Loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2007-0352

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Hainerová, I., Larsen, L. H., Holst, B., Finková, M., Hainer, V., Lebl, J., Hansen, T., & Pedersen, O. (2007). Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. Journal of Clinical Endocrinology and Metabolism, 92(9), 3689-96. https://doi.org/10.1210/jc.2007-0352

Melanocortin 4 receptor mutations in obese Czech children : studies of prevalence, phenotype development, weight reduction response, and functional analysis. / Hainerová, Irena; Larsen, Lesli H; Holst, Birgitte et al.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 9, 2007, p. 3689-96.

Research output: Contribution to journal › Journal article › Research › peer-review

Hainerová, I, Larsen, LH, Holst, B, Finková, M, Hainer, V, Lebl, J, Hansen, T & Pedersen, O 2007, 'Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 9, pp. 3689-96. https://doi.org/10.1210/jc.2007-0352

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abstract = "Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common known cause of monogenic human obesity.",

keywords = "Adolescent, Adult, Body Height, Body Weight, Case-Control Studies, Child, Child, Preschool, Czech Republic, DNA Mutational Analysis, Female, Follow-Up Studies, Gene Frequency, Humans, Male, Models, Biological, Mutation, Obesity, Pedigree, Phenotype, Receptor, Melanocortin, Type 4, Weight Loss",

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AU - Hainerová, Irena

AU - Larsen, Lesli H

AU - Holst, Birgitte

AU - Finková, Marie

AU - Hainer, Vojtech

AU - Lebl, Jan

AU - Hansen, Torben

AU - Pedersen, Oluf

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KW - Body Height

KW - Body Weight

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Czech Republic

KW - DNA Mutational Analysis

KW - Female

KW - Follow-Up Studies

KW - Gene Frequency

KW - Humans

KW - Male

KW - Models, Biological

KW - Mutation

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KW - Pedigree

KW - Phenotype

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DO - 10.1210/jc.2007-0352

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 9

ER -

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis

Abstract

Keywords

UN SDGs

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