Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

Lasse Skibsbye; Ursula Ravens

doi:10.1016/j.ccep.2016.02.004

Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

Lasse Skibsbye, Ursula Ravens

9 Citations (Scopus)

Abstract

Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.

Original language	English
Journal	Cardiac Electrophysiology Clinics
Volume	8
Issue number	2
Pages (from-to)	395-410
Number of pages	16
ISSN	1877-9182
DOIs	https://doi.org/10.1016/j.ccep.2016.02.004
Publication status	Published - 1 Jun 2016

Keywords

Action Potentials
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Heart Conduction System
Humans
Mice
Potassium Channel Blockers
Journal Article
Review

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10.1016/j.ccep.2016.02.004

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title = "Mechanism of Proarrhythmic Effects of Potassium Channel Blockers",

abstract = "Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.",

keywords = "Action Potentials, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Heart Conduction System, Humans, Mice, Potassium Channel Blockers, Journal Article, Review",

author = "Lasse Skibsbye and Ursula Ravens",

year = "2016",

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doi = "10.1016/j.ccep.2016.02.004",

language = "English",

volume = "8",

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journal = "Cardiac Electrophysiology Clinics",

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publisher = "W.B.Saunders Co.",

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TY - JOUR

T1 - Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

AU - Skibsbye, Lasse

AU - Ravens, Ursula

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.

AB - Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.

KW - Action Potentials

KW - Animals

KW - Anti-Arrhythmia Agents

KW - Arrhythmias, Cardiac

KW - Heart Conduction System

KW - Humans

KW - Mice

KW - Potassium Channel Blockers

KW - Journal Article

KW - Review

U2 - 10.1016/j.ccep.2016.02.004

DO - 10.1016/j.ccep.2016.02.004

M3 - Journal article

C2 - 27261830

SN - 1877-9182

VL - 8

SP - 395

EP - 410

JO - Cardiac Electrophysiology Clinics

JF - Cardiac Electrophysiology Clinics

IS - 2

ER -

Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

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