Measurement of brain oxygenation changes using dynamic T1-weighted imaging

Bryan Haddock; Henrik B W Larsson; Adam E Hansen; Egill Rostrup

doi:10.1016/j.neuroimage.2013.03.068

Measurement of brain oxygenation changes using dynamic T1-weighted imaging

Bryan Haddock, Henrik B W Larsson, Adam E Hansen, Egill Rostrup

13 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) has proven useful in evaluating oxygenation in several types of tissue and blood. This study evaluates brain tissue oxygenation changes between normoxia and hyperoxia in healthy subjects using dynamic T₁ and T₂*-weighted imaging sequences. The change in F_iO₂ induced by hyperoxia caused a significant decrease in T₁. A model to determine changes in tissue oxygen tension from the T₁-weighted MRI signal is presented based on previous findings that T₁ is sensitive to oxygen tension whereas T₂* is sensitive to blood saturation. The two sequences produce results with different regional and temporal dynamics. These differences combined with results from simulations of the T₁ signal intensities, indicate an increase in extravascular oxygen tension during hyperoxia. This study concludes that T₁ and T₂* responses to F_iO₂ serve as independent biomarkers of oxygen physiology in the brain with a potential to provide quantitative information on tissue oxygenation.

Original language	English
Journal	NeuroImage
Volume	78
Pages (from-to)	7-15
Number of pages	9
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2013.03.068
Publication status	Published - Sept 2013

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title = "Measurement of brain oxygenation changes using dynamic T1-weighted imaging",

abstract = "Magnetic resonance imaging (MRI) has proven useful in evaluating oxygenation in several types of tissue and blood. This study evaluates brain tissue oxygenation changes between normoxia and hyperoxia in healthy subjects using dynamic T1 and T2*-weighted imaging sequences. The change in FiO2 induced by hyperoxia caused a significant decrease in T1. A model to determine changes in tissue oxygen tension from the T1-weighted MRI signal is presented based on previous findings that T1 is sensitive to oxygen tension whereas T2* is sensitive to blood saturation. The two sequences produce results with different regional and temporal dynamics. These differences combined with results from simulations of the T1 signal intensities, indicate an increase in extravascular oxygen tension during hyperoxia. This study concludes that T1 and T2* responses to FiO2 serve as independent biomarkers of oxygen physiology in the brain with a potential to provide quantitative information on tissue oxygenation.",

author = "Bryan Haddock and Larsson, {Henrik B W} and Hansen, {Adam E} and Egill Rostrup",

year = "2013",

month = sep,

doi = "10.1016/j.neuroimage.2013.03.068",

language = "English",

volume = "78",

pages = "7--15",

journal = "NeuroImage",

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T1 - Measurement of brain oxygenation changes using dynamic T1-weighted imaging

AU - Haddock, Bryan

AU - Larsson, Henrik B W

AU - Hansen, Adam E

AU - Rostrup, Egill

PY - 2013/9

Y1 - 2013/9

N2 - Magnetic resonance imaging (MRI) has proven useful in evaluating oxygenation in several types of tissue and blood. This study evaluates brain tissue oxygenation changes between normoxia and hyperoxia in healthy subjects using dynamic T1 and T2*-weighted imaging sequences. The change in FiO2 induced by hyperoxia caused a significant decrease in T1. A model to determine changes in tissue oxygen tension from the T1-weighted MRI signal is presented based on previous findings that T1 is sensitive to oxygen tension whereas T2* is sensitive to blood saturation. The two sequences produce results with different regional and temporal dynamics. These differences combined with results from simulations of the T1 signal intensities, indicate an increase in extravascular oxygen tension during hyperoxia. This study concludes that T1 and T2* responses to FiO2 serve as independent biomarkers of oxygen physiology in the brain with a potential to provide quantitative information on tissue oxygenation.

AB - Magnetic resonance imaging (MRI) has proven useful in evaluating oxygenation in several types of tissue and blood. This study evaluates brain tissue oxygenation changes between normoxia and hyperoxia in healthy subjects using dynamic T1 and T2*-weighted imaging sequences. The change in FiO2 induced by hyperoxia caused a significant decrease in T1. A model to determine changes in tissue oxygen tension from the T1-weighted MRI signal is presented based on previous findings that T1 is sensitive to oxygen tension whereas T2* is sensitive to blood saturation. The two sequences produce results with different regional and temporal dynamics. These differences combined with results from simulations of the T1 signal intensities, indicate an increase in extravascular oxygen tension during hyperoxia. This study concludes that T1 and T2* responses to FiO2 serve as independent biomarkers of oxygen physiology in the brain with a potential to provide quantitative information on tissue oxygenation.

U2 - 10.1016/j.neuroimage.2013.03.068

DO - 10.1016/j.neuroimage.2013.03.068

M3 - Journal article

C2 - 23578574

SN - 1053-8119

VL - 78

SP - 7

EP - 15

JO - NeuroImage

JF - NeuroImage

ER -

Measurement of brain oxygenation changes using dynamic T1-weighted imaging

Abstract

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