Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Morten Andersen; Zamra Sajid; Rasmus K. Pedersen; Johanne Gudmand-hoeyer; Christina Ellervik; Vibe Skov; Lasse Kjær; Niels Pallisgaard; Torben A. Kruse; Mads Thomassen; Jesper Troelsen; Hans Carl Hasselbalch; Johnny T. Ottesen

doi:10.1371/journal.pone.0183620

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Morten Andersen, Zamra Sajid, Rasmus K. Pedersen, Johanne Gudmand-hoeyer, Christina Ellervik, Vibe Skov, Lasse Kjær, Niels Pallisgaard, Torben A. Kruse, Mads Thomassen, Jesper Troelsen, Hans Carl Hasselbalch, Johnny T. Ottesen

Department of Clinical Medicine

22 Citations (Scopus)

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Abstract

The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as “A Human Inflammation Model for Cancer Development“. This novel concept has been built upon clinical, experimental, genomic, immunological and not least epidemiological studies. Only a few studies have described the development of MPNs by mathematical models, and none have addressed the role of inflammation for clonal evolution and disease progression. Herein, we aim at using mathematical modelling to substantiate the concept of chronic inflammation as an important trigger and driver of MPNs.The basics of the model describe the proliferation from stem cells to mature cells including mutations of healthy stem cells to become malignant stem cells. We include a simple inflammatory coupling coping with cell death and affecting the basic model beneath. First, we describe the system without feedbacks or regulatory interactions. Next, we introduce inflammatory feedback into the system. Finally, we include other feedbacks and regulatory interactions forming the inflammatory-MPN model. Using mathematical modeling, we add further proof to the concept that chronic inflammation may be both a trigger of clonal evolution and an important driving force for MPN disease progression. Our findings support intervention at the earliest stage of cancer development to target the malignant clone and dampen concomitant inflammation.

Original language	English
Article number	e0183620
Journal	PLOS ONE
Volume	12
Issue number	8
Number of pages	18
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0183620
Publication status	Published - Aug 2017

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Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer developmentFinal published version, 0.99 MBLicence: CC BY

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Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, H. C., & Ottesen, J. T. (2017). Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development. PLOS ONE, 12(8), Article e0183620. https://doi.org/10.1371/journal.pone.0183620

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title = "Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development",

abstract = "The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as “A Human Inflammation Model for Cancer Development“. This novel concept has been built upon clinical, experimental, genomic, immunological and not least epidemiological studies. Only a few studies have described the development of MPNs by mathematical models, and none have addressed the role of inflammation for clonal evolution and disease progression. Herein, we aim at using mathematical modelling to substantiate the concept of chronic inflammation as an important trigger and driver of MPNs.The basics of the model describe the proliferation from stem cells to mature cells including mutations of healthy stem cells to become malignant stem cells. We include a simple inflammatory coupling coping with cell death and affecting the basic model beneath. First, we describe the system without feedbacks or regulatory interactions. Next, we introduce inflammatory feedback into the system. Finally, we include other feedbacks and regulatory interactions forming the inflammatory-MPN model. Using mathematical modeling, we add further proof to the concept that chronic inflammation may be both a trigger of clonal evolution and an important driving force for MPN disease progression. Our findings support intervention at the earliest stage of cancer development to target the malignant clone and dampen concomitant inflammation.",

author = "Morten Andersen and Zamra Sajid and Pedersen, {Rasmus K.} and Johanne Gudmand-hoeyer and Christina Ellervik and Vibe Skov and Lasse Kj{\ae}r and Niels Pallisgaard and Kruse, {Torben A.} and Mads Thomassen and Jesper Troelsen and Hasselbalch, {Hans Carl} and Ottesen, {Johnny T.}",

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AU - Ellervik, Christina

AU - Skov, Vibe

AU - Kjær, Lasse

AU - Pallisgaard, Niels

AU - Kruse, Torben A.

AU - Thomassen, Mads

AU - Troelsen, Jesper

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AU - Ottesen, Johnny T.

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N2 - The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as “A Human Inflammation Model for Cancer Development“. This novel concept has been built upon clinical, experimental, genomic, immunological and not least epidemiological studies. Only a few studies have described the development of MPNs by mathematical models, and none have addressed the role of inflammation for clonal evolution and disease progression. Herein, we aim at using mathematical modelling to substantiate the concept of chronic inflammation as an important trigger and driver of MPNs.The basics of the model describe the proliferation from stem cells to mature cells including mutations of healthy stem cells to become malignant stem cells. We include a simple inflammatory coupling coping with cell death and affecting the basic model beneath. First, we describe the system without feedbacks or regulatory interactions. Next, we introduce inflammatory feedback into the system. Finally, we include other feedbacks and regulatory interactions forming the inflammatory-MPN model. Using mathematical modeling, we add further proof to the concept that chronic inflammation may be both a trigger of clonal evolution and an important driving force for MPN disease progression. Our findings support intervention at the earliest stage of cancer development to target the malignant clone and dampen concomitant inflammation.

AB - The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as “A Human Inflammation Model for Cancer Development“. This novel concept has been built upon clinical, experimental, genomic, immunological and not least epidemiological studies. Only a few studies have described the development of MPNs by mathematical models, and none have addressed the role of inflammation for clonal evolution and disease progression. Herein, we aim at using mathematical modelling to substantiate the concept of chronic inflammation as an important trigger and driver of MPNs.The basics of the model describe the proliferation from stem cells to mature cells including mutations of healthy stem cells to become malignant stem cells. We include a simple inflammatory coupling coping with cell death and affecting the basic model beneath. First, we describe the system without feedbacks or regulatory interactions. Next, we introduce inflammatory feedback into the system. Finally, we include other feedbacks and regulatory interactions forming the inflammatory-MPN model. Using mathematical modeling, we add further proof to the concept that chronic inflammation may be both a trigger of clonal evolution and an important driving force for MPN disease progression. Our findings support intervention at the earliest stage of cancer development to target the malignant clone and dampen concomitant inflammation.

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Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

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