Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Michael Christiansen; Paula L Hedley; Sophie Placing; Karen R Wøjdemann; Anting L Carlsen; Jennifer M Jørgensen; Anne-Cathrine Gjerris; Anne-Cathrine Shalmi; Line Rode; Karin Sundberg; Ann Tabor

doi:10.3109/10641955.2014.913615

Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Michael Christiansen, Paula L Hedley, Sophie Placing, Karen R Wøjdemann, Anting L Carlsen, Jennifer M Jørgensen, Anne-Cathrine Gjerris, Anne-Cathrine Shalmi, Line Rode, Karin Sundberg, Ann Tabor

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

OBJECTIVE: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).

METHODS: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10(+0)-13(+6).

RESULTS: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.

CONCLUSIONS: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.

Original language	English
Journal	Hypertension in Pregnancy
Volume	34
Issue number	4
Pages (from-to)	422-433
Number of pages	12
ISSN	1064-1955
DOIs	https://doi.org/10.3109/10641955.2014.913615
Publication status	Published - 2 Oct 2015

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Christiansen, M., Hedley, P. L., Placing, S., Wøjdemann, K. R., Carlsen, A. L., Jørgensen, J. M., Gjerris, A-C., Shalmi, A-C., Rode, L., Sundberg, K., & Tabor, A. (2015). Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity. Hypertension in Pregnancy, 34(4), 422-433. https://doi.org/10.3109/10641955.2014.913615

Christiansen, M, Hedley, PL, Placing, S, Wøjdemann, KR, Carlsen, AL, Jørgensen, JM, Gjerris, A-C, Shalmi, A-C, Rode, L, Sundberg, K & Tabor, A 2015, 'Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity', Hypertension in Pregnancy, vol. 34, no. 4, pp. 422-433. https://doi.org/10.3109/10641955.2014.913615

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title = "Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity",

abstract = "OBJECTIVE: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).METHODS: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10(+0)-13(+6).RESULTS: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.CONCLUSIONS: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.",

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doi = "10.3109/10641955.2014.913615",

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T1 - Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

AU - Christiansen, Michael

AU - Hedley, Paula L

AU - Placing, Sophie

AU - Wøjdemann, Karen R

AU - Carlsen, Anting L

AU - Jørgensen, Jennifer M

AU - Gjerris, Anne-Cathrine

AU - Shalmi, Anne-Cathrine

AU - Rode, Line

AU - Sundberg, Karin

AU - Tabor, Ann

PY - 2015/10/2

Y1 - 2015/10/2

N2 - OBJECTIVE: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).METHODS: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10(+0)-13(+6).RESULTS: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.CONCLUSIONS: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.

AB - OBJECTIVE: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).METHODS: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10(+0)-13(+6).RESULTS: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.CONCLUSIONS: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.

U2 - 10.3109/10641955.2014.913615

DO - 10.3109/10641955.2014.913615

M3 - Journal article

C2 - 26636480

SN - 1064-1955

VL - 34

SP - 422

EP - 433

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

IS - 4

ER -

Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity

Abstract

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