Maternal obesity reprograms offspring's executive brain centers in a sex-specific manner?: An Editorial for "Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain" on page 362

Kaja Plucińska; Steven W Barger

doi:10.1111/jnc.14334

Maternal obesity reprograms offspring's executive brain centers in a sex-specific manner? An Editorial for "Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain" on page 362

2 Citations (Scopus)

Abstract

This editorial highlights an article by McKee and colleagues in the current issue of Journal of Neurochemistry, in which the authors report epigenetic changes linked to one-carbon metabolism in prefrontal cortex (PFC) of murine offspring from dams fed high-fat diet to mimic maternal obesity. The group found that high-fat diet feeding in utero increases weight gain in offspring and dynamically alters DNA methylation in the PFC of male but not female brains. These epigenetic marks were associated with a shift in brain one-carbon metabolism (folate and methionine) intermediates and were normalized by early-life methyl-donor supplementation in a sex-specific manner. (Figure presented.).

Original language	English
Journal	Journal of Neurochemistry
Volume	145
Issue number	5
Pages (from-to)	358-361
ISSN	0022-3042
DOIs	https://doi.org/10.1111/jnc.14334
Publication status	Published - Jun 2018

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Maternal obesity reprograms offspring's executive brain centers in a sex-specific manner? An Editorial for "Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain" on page 362. / Plucińska, Kaja; Barger, Steven W.

In: Journal of Neurochemistry, Vol. 145, No. 5, 06.2018, p. 358-361.

Research output: Contribution to journal › Editorial

Plucińska, K & Barger, SW 2018, 'Maternal obesity reprograms offspring's executive brain centers in a sex-specific manner? An Editorial for "Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain" on page 362', Journal of Neurochemistry, vol. 145, no. 5, pp. 358-361. https://doi.org/10.1111/jnc.14334

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