Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Navneet A Vasistha; Maria Pardo-Navarro; Janina Gasthaus; Dilys Weijers; Michaela K Müller; Diego García-González; Susmita Malwade; Irina Korshunova; Ulrich Pfisterer; Jakob von Engelhardt; Karin S Hougaard; Konstantin Khodosevich

doi:10.1038/s41380-019-0539-5

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Navneet A Vasistha, Maria Pardo-Navarro, Janina Gasthaus, Dilys Weijers, Michaela K Müller, Diego García-González, Susmita Malwade, Irina Korshunova, Ulrich Pfisterer, Jakob von Engelhardt, Karin S Hougaard, Konstantin Khodosevich

Section of Environmental Health

13 Citations (Scopus)

Abstract

Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result of maternal inflammation. This translated into a reduction in cell numbers, redistribution across cortical regions and layers, and changes in morphology and cellular properties. Furthermore, selective vulnerability of GABAergic interneuron subtypes was associated with the stage of brain development. Thus, we propose that maternally derived insults have developmental stage-dependent effects, which contribute to the complex etiology of cognitive impairment in the affected offspring.

Original language	English
Journal	Molecular Psychiatry
ISSN	1359-4184
DOIs	https://doi.org/10.1038/s41380-019-0539-5
Publication status	Published - 1 Oct 2020

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Vasistha, N. A., Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., García-González, D., Malwade, S., Korshunova, I., Pfisterer, U., von Engelhardt, J., Hougaard, K. S., & Khodosevich, K. (2020). Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner. Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0539-5

Vasistha, NA, Pardo-Navarro, M, Gasthaus, J, Weijers, D, Müller, MK, García-González, D, Malwade, S, Korshunova, I, Pfisterer, U, von Engelhardt, J, Hougaard, KS & Khodosevich, K 2020, 'Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner', Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0539-5

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title = "Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner",

abstract = "Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result of maternal inflammation. This translated into a reduction in cell numbers, redistribution across cortical regions and layers, and changes in morphology and cellular properties. Furthermore, selective vulnerability of GABAergic interneuron subtypes was associated with the stage of brain development. Thus, we propose that maternally derived insults have developmental stage-dependent effects, which contribute to the complex etiology of cognitive impairment in the affected offspring.",

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AU - Vasistha, Navneet A

AU - Pardo-Navarro, Maria

AU - Gasthaus, Janina

AU - Weijers, Dilys

AU - Müller, Michaela K

AU - García-González, Diego

AU - Malwade, Susmita

AU - Korshunova, Irina

AU - Pfisterer, Ulrich

AU - von Engelhardt, Jakob

AU - Hougaard, Karin S

AU - Khodosevich, Konstantin

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result of maternal inflammation. This translated into a reduction in cell numbers, redistribution across cortical regions and layers, and changes in morphology and cellular properties. Furthermore, selective vulnerability of GABAergic interneuron subtypes was associated with the stage of brain development. Thus, we propose that maternally derived insults have developmental stage-dependent effects, which contribute to the complex etiology of cognitive impairment in the affected offspring.

AB - Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result of maternal inflammation. This translated into a reduction in cell numbers, redistribution across cortical regions and layers, and changes in morphology and cellular properties. Furthermore, selective vulnerability of GABAergic interneuron subtypes was associated with the stage of brain development. Thus, we propose that maternally derived insults have developmental stage-dependent effects, which contribute to the complex etiology of cognitive impairment in the affected offspring.

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DO - 10.1038/s41380-019-0539-5

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SN - 1359-4184

JO - Molecular Psychiatry

JF - Molecular Psychiatry

ER -

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Abstract

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