Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)

Eleni Papadopoulou; Manolis Kogevinas; Maria Botsivali; Marie Pedersen; Harrie Besselink; Michelle A Mendez; Sarah Fleming; Laura J Hardie; Lisbeth E Knudsen; John Wright; Silvia Agramunt; Jordi Sunyer; Berit Granum; Kristine B Gutzkow; Gunnar Brunborg; Jan Alexander; Helle Margrete Meltzer; Anne Lise Brantsæter; Katerina Sarri; Leda Chatzi; Domenico F Merlo; Jos C Kleinjans; Margaretha Haugen

doi:10.1016/j.scitotenv.2014.03.047

Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)

Eleni Papadopoulou, Manolis Kogevinas, Maria Botsivali, Marie Pedersen, Harrie Besselink, Michelle A Mendez, Sarah Fleming, Laura J Hardie, Lisbeth E Knudsen, John Wright, Silvia Agramunt, Jordi Sunyer, Berit Granum, Kristine B Gutzkow, Gunnar Brunborg, Jan Alexander, Helle Margrete Meltzer, Anne Lise Brantsæter, Katerina Sarri, Leda ChatziDomenico F Merlo, Jos C Kleinjans, Margaretha Haugen

Section of Environmental Health

24 Citations (Scopus)

Abstract

Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of -121g (95% confidence intervals: -232, -10g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (-1.4days, 95% CI: -3.8, 1.0days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.

Original language	English
Journal	The Science of the Total Environment
Volume	484
Pages (from-to)	121-8
Number of pages	8
ISSN	0048-9697
DOIs	https://doi.org/10.1016/j.scitotenv.2014.03.047
Publication status	Published - 15 Jun 2014

Access to Document

10.1016/j.scitotenv.2014.03.047

Cite this

Papadopoulou, E., Kogevinas, M., Botsivali, M., Pedersen, M., Besselink, H., Mendez, M. A., Fleming, S., Hardie, L. J., Knudsen, L. E., Wright, J., Agramunt, S., Sunyer, J., Granum, B., Gutzkow, K. B., Brunborg, G., Alexander, J., Meltzer, H. M., Brantsæter, A. L., Sarri, K., ... Haugen, M. (2014). Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris). The Science of the Total Environment, 484, 121-8. https://doi.org/10.1016/j.scitotenv.2014.03.047

Papadopoulou, E, Kogevinas, M, Botsivali, M, Pedersen, M, Besselink, H, Mendez, MA, Fleming, S, Hardie, LJ, Knudsen, LE, Wright, J, Agramunt, S, Sunyer, J, Granum, B, Gutzkow, KB, Brunborg, G, Alexander, J, Meltzer, HM, Brantsæter, AL, Sarri, K, Chatzi, L, Merlo, DF, Kleinjans, JC & Haugen, M 2014, 'Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)', The Science of the Total Environment, vol. 484, pp. 121-8. https://doi.org/10.1016/j.scitotenv.2014.03.047

@article{9579fa8431ae4112a4e3bd05c77ad3c3,

title = "Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)",

abstract = "Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX{\textregistered}) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX{\textregistered}) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of -121g (95% confidence intervals: -232, -10g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (-1.4days, 95% CI: -3.8, 1.0days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.",

author = "Eleni Papadopoulou and Manolis Kogevinas and Maria Botsivali and Marie Pedersen and Harrie Besselink and Mendez, {Michelle A} and Sarah Fleming and Hardie, {Laura J} and Knudsen, {Lisbeth E} and John Wright and Silvia Agramunt and Jordi Sunyer and Berit Granum and Gutzkow, {Kristine B} and Gunnar Brunborg and Jan Alexander and Meltzer, {Helle Margrete} and Brants{\ae}ter, {Anne Lise} and Katerina Sarri and Leda Chatzi and Merlo, {Domenico F} and Kleinjans, {Jos C} and Margaretha Haugen",

year = "2014",

month = jun,

day = "15",

doi = "10.1016/j.scitotenv.2014.03.047",

language = "English",

volume = "484",

pages = "121--8",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier",

}

TY - JOUR

T1 - Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)

AU - Papadopoulou, Eleni

AU - Kogevinas, Manolis

AU - Botsivali, Maria

AU - Pedersen, Marie

AU - Besselink, Harrie

AU - Mendez, Michelle A

AU - Fleming, Sarah

AU - Hardie, Laura J

AU - Knudsen, Lisbeth E

AU - Wright, John

AU - Agramunt, Silvia

AU - Sunyer, Jordi

AU - Granum, Berit

AU - Gutzkow, Kristine B

AU - Brunborg, Gunnar

AU - Alexander, Jan

AU - Meltzer, Helle Margrete

AU - Brantsæter, Anne Lise

AU - Sarri, Katerina

AU - Chatzi, Leda

AU - Merlo, Domenico F

AU - Kleinjans, Jos C

AU - Haugen, Margaretha

PY - 2014/6/15

Y1 - 2014/6/15

N2 - Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of -121g (95% confidence intervals: -232, -10g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (-1.4days, 95% CI: -3.8, 1.0days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.

AB - Maternal diet can result in exposure to environmental contaminants including dioxins which may influence foetal growth. We investigated the association between maternal diet and birth outcomes by defining a dioxin-rich diet. We used validated food frequency questionnaires to assess the diet of pregnant women from Greece, Spain, United Kingdom, Denmark and Norway and estimated plasma dioxin-like activity by the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR-CALUX®) bioassay in 604 maternal blood samples collected at delivery. We applied reduced rank regression to identify a dioxin-rich dietary pattern based on dioxin-like activity (DR-CALUX®) levels in maternal plasma, and calculated a dioxin-diet score as an estimate of adherence to this dietary pattern. In the five country population, dioxin-diet score was characterised by high consumption of red and white meat, lean and fatty fish, low-fat dairy and low consumption of salty snacks and high-fat cheese, during pregnancy. The upper tertile of the dioxin-diet score was associated with a change in birth weight of -121g (95% confidence intervals: -232, -10g) compared to the lower tertile after adjustment for confounders. A small non-significant reduction in gestational age was also observed (-1.4days, 95% CI: -3.8, 1.0days). Our results suggest that maternal diet might contribute to the exposure of the foetus to dioxins and dioxin-like compounds and may be related to reduced birth weight. More studies are needed to develop updated dietary guidelines for women of reproductive age, aiming to the reduction of dietary exposure to persistent organic pollutants as dioxins and dioxin-like compounds.

U2 - 10.1016/j.scitotenv.2014.03.047

DO - 10.1016/j.scitotenv.2014.03.047

M3 - Journal article

C2 - 24691212

SN - 0048-9697

VL - 484

SP - 121

EP - 128

JO - Science of the Total Environment

JF - Science of the Total Environment

ER -

Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother–child study (NewGeneris)

Abstract

Access to Document

Fingerprint

Cite this