Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

Cristina O'Callaghan-Gordo; Manolis Kogevinas; Marie Pedersen; Eleni Fthenou; Ana Espinosa; Xristina Tsiapa; Georgia Chalkiadaki; Vasiliki Daraki; Eirini Dermitzaki; Ilse Decordier; Peter B. Farmer; Panagiotis Georgiadis; Vaggelis Georgiou; Soterios A. Kyrtopoulos; Domenico Franco Merlo; Dora Romaguera; Theano Roumeliotaki; Katerina Sarri; Margareta Törnqvist; Kim Vande Loock; Hans von Stedingk; Jos Kleinjans; Micheline Kirsch-Volders; Leda Chatzi

doi:10.1007/s00394-016-1310-1

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

Cristina O'Callaghan-Gordo, Manolis Kogevinas, Marie Pedersen, Eleni Fthenou, Ana Espinosa, Xristina Tsiapa, Georgia Chalkiadaki, Vasiliki Daraki, Eirini Dermitzaki, Ilse Decordier, Peter B. Farmer, Panagiotis Georgiadis, Vaggelis Georgiou, Soterios A. Kyrtopoulos, Domenico Franco Merlo, Dora Romaguera, Theano Roumeliotaki, Katerina Sarri, Margareta Törnqvist, Kim Vande LoockHans von Stedingk, Jos Kleinjans, Micheline Kirsch-Volders, Leda Chatzi

Center of Epidemiology and Screening

9 Citations (Scopus)

Abstract

PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.

METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).

RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.

CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

Original language	English
Journal	European Journal of Nutrition
Volume	57
Issue number	1
Pages (from-to)	209–218
Number of pages	10
ISSN	1436-6207
DOIs	https://doi.org/10.1007/s00394-016-1310-1
Publication status	Published - 1 Feb 2018

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O'Callaghan-Gordo, C., Kogevinas, M., Pedersen, M., Fthenou, E., Espinosa, A., Tsiapa, X., Chalkiadaki, G., Daraki, V., Dermitzaki, E., Decordier, I., Farmer, P. B., Georgiadis, P., Georgiou, V., Kyrtopoulos, S. A., Merlo, D. F., Romaguera, D., Roumeliotaki, T., Sarri, K., Törnqvist, M., ... Chatzi, L. (2018). Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). European Journal of Nutrition, 57(1), 209–218. https://doi.org/10.1007/s00394-016-1310-1

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). / O'Callaghan-Gordo, Cristina; Kogevinas, Manolis; Pedersen, Marie et al.

In: European Journal of Nutrition, Vol. 57, No. 1, 01.02.2018, p. 209–218.

Research output: Contribution to journal › Journal article › Research › peer-review

O'Callaghan-Gordo, C, Kogevinas, M, Pedersen, M, Fthenou, E, Espinosa, A, Tsiapa, X, Chalkiadaki, G, Daraki, V, Dermitzaki, E, Decordier, I, Farmer, PB, Georgiadis, P, Georgiou, V, Kyrtopoulos, SA, Merlo, DF, Romaguera, D, Roumeliotaki, T, Sarri, K, Törnqvist, M, Loock, KV, von Stedingk, H, Kleinjans, J, Kirsch-Volders, M & Chatzi, L 2018, 'Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)', European Journal of Nutrition, vol. 57, no. 1, pp. 209–218. https://doi.org/10.1007/s00394-016-1310-1

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title = "Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)",

abstract = "PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.",

author = "Cristina O'Callaghan-Gordo and Manolis Kogevinas and Marie Pedersen and Eleni Fthenou and Ana Espinosa and Xristina Tsiapa and Georgia Chalkiadaki and Vasiliki Daraki and Eirini Dermitzaki and Ilse Decordier and Farmer, {Peter B.} and Panagiotis Georgiadis and Vaggelis Georgiou and Kyrtopoulos, {Soterios A.} and Merlo, {Domenico Franco} and Dora Romaguera and Theano Roumeliotaki and Katerina Sarri and Margareta T{\"o}rnqvist and Loock, {Kim Vande} and {von Stedingk}, Hans and Jos Kleinjans and Micheline Kirsch-Volders and Leda Chatzi",

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doi = "10.1007/s00394-016-1310-1",

language = "English",

volume = "57",

pages = "209–218",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "Springer Medizin",

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TY - JOUR

T1 - Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

AU - O'Callaghan-Gordo, Cristina

AU - Kogevinas, Manolis

AU - Pedersen, Marie

AU - Fthenou, Eleni

AU - Espinosa, Ana

AU - Tsiapa, Xristina

AU - Chalkiadaki, Georgia

AU - Daraki, Vasiliki

AU - Dermitzaki, Eirini

AU - Decordier, Ilse

AU - Farmer, Peter B.

AU - Georgiadis, Panagiotis

AU - Georgiou, Vaggelis

AU - Kyrtopoulos, Soterios A.

AU - Merlo, Domenico Franco

AU - Romaguera, Dora

AU - Roumeliotaki, Theano

AU - Sarri, Katerina

AU - Törnqvist, Margareta

AU - Loock, Kim Vande

AU - von Stedingk, Hans

AU - Kleinjans, Jos

AU - Kirsch-Volders, Micheline

AU - Chatzi, Leda

PY - 2018/2/1

Y1 - 2018/2/1

N2 - PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

AB - PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.

U2 - 10.1007/s00394-016-1310-1

DO - 10.1007/s00394-016-1310-1

M3 - Journal article

C2 - 27655526

SN - 1436-6207

VL - 57

SP - 209

EP - 218

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 1

ER -

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)

Abstract

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