Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method.

K Murase; H Kuwabara; Y Yasuhara; A C Evans; A Gjedde

doi:10.1109/42.544500

Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method.

K Murase, H Kuwabara, Y Yasuhara, A C Evans, A Gjedde

6 Citations (Scopus)

Abstract

The authors developed a method for mapping the change in cerebral glucose utilization at two different physiological states using [(18 )F]fluorodeoxyglucose (FDC) double infection and the constrained weighted-integration method. The authors studied young normal subjects without (baseline-baseline group, n=5) and with (baseline-stimulation group, n=5) vibrotactile stimulation of the fingertips of the right hand. Dynamic scans were performed using positron emission tomography (PET) following an initial dose (the first session, 0-30 min) and an additional dose (the second session, 30-60 min). The parametric images of the net clearance of FDG from blood to brain (K*), unidirectional blood-to-brain clearance (K(1)*), and cerebral metabolic rate of glucose (CMR(glc)) of the two sessions were generated. The averaged subtraction (second minus first session) and t-statistic images were generated, which were rendered into Talairach's stereotaxic coordinates and merged with the averaged magnetic resonance imaging (MRI) image. In the baseline-baseline group, regional K*, K(1)* and CMR(glc) in the first and second sessions were strongly correlated (r(2)=0.953, 0.935, and 0.951, respectively, n=330). In the baseline-stimulation group, significant increases in these estimates were obtained in the contralateral primary somatosensory cortex (SI) (from 3.43+/-0.78 to 4.02+/-1.01 ml/100 g/min for K*, 7.85+/-1.88 to 9.09+/-1.71 ml/100 g/min for K(1)*, and 280+/-5.9 to 32.3+/-5.5 mumol/100 g/min for CMR(glc)), while there were no significant changes in the ipsilateral SI (from 3.45+/-0.83 to 359+/-0.72 ml/100 g/min for K*, 8.17+/-2.33 to 837+/-1.75 ml/100 g/min for K(1 )* and 29.5+/-8.1 to 29.1+/-8.2 mumol/100 g/mln for CMR (glc)), Significant increases in K* and CMR(glc) in the contralateral SI were clearly demonstrated in the t-statistic image. In conclusion, the proposed method allows mapping of changes in cerebral glucose utilization during physiological stimulation of the brain, and will be useful for studying the relationship between neural activity and regional cerebral glucose metabolism.

Original language	English
Journal	IEEE Transactions on Medical Imaging
Volume	15
Issue number	6
Pages (from-to)	824-35
Number of pages	11
ISSN	0278-0062
DOIs	https://doi.org/10.1109/42.544500
Publication status	Published - 1996
Externally published	Yes

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10.1109/42.544500

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@article{22001750b31511debc73000ea68e967b,

title = "Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method.",

abstract = "The authors developed a method for mapping the change in cerebral glucose utilization at two different physiological states using [(18 )F]fluorodeoxyglucose (FDC) double infection and the constrained weighted-integration method. The authors studied young normal subjects without (baseline-baseline group, n=5) and with (baseline-stimulation group, n=5) vibrotactile stimulation of the fingertips of the right hand. Dynamic scans were performed using positron emission tomography (PET) following an initial dose (the first session, 0-30 min) and an additional dose (the second session, 30-60 min). The parametric images of the net clearance of FDG from blood to brain (K*), unidirectional blood-to-brain clearance (K(1)*), and cerebral metabolic rate of glucose (CMR(glc)) of the two sessions were generated. The averaged subtraction (second minus first session) and t-statistic images were generated, which were rendered into Talairach's stereotaxic coordinates and merged with the averaged magnetic resonance imaging (MRI) image. In the baseline-baseline group, regional K*, K(1)* and CMR(glc) in the first and second sessions were strongly correlated (r(2)=0.953, 0.935, and 0.951, respectively, n=330). In the baseline-stimulation group, significant increases in these estimates were obtained in the contralateral primary somatosensory cortex (SI) (from 3.43+/-0.78 to 4.02+/-1.01 ml/100 g/min for K*, 7.85+/-1.88 to 9.09+/-1.71 ml/100 g/min for K(1)*, and 280+/-5.9 to 32.3+/-5.5 mumol/100 g/min for CMR(glc)), while there were no significant changes in the ipsilateral SI (from 3.45+/-0.83 to 359+/-0.72 ml/100 g/min for K*, 8.17+/-2.33 to 837+/-1.75 ml/100 g/min for K(1 )* and 29.5+/-8.1 to 29.1+/-8.2 mumol/100 g/mln for CMR (glc)), Significant increases in K* and CMR(glc) in the contralateral SI were clearly demonstrated in the t-statistic image. In conclusion, the proposed method allows mapping of changes in cerebral glucose utilization during physiological stimulation of the brain, and will be useful for studying the relationship between neural activity and regional cerebral glucose metabolism.",

author = "K Murase and H Kuwabara and Y Yasuhara and Evans, {A C} and A Gjedde",

year = "1996",

doi = "10.1109/42.544500",

language = "English",

volume = "15",

pages = "824--35",

journal = "I E E E Transactions on Medical Imaging",

issn = "0278-0062",

publisher = "Institute of Electrical and Electronics Engineers",

number = "6",

}

TY - JOUR

T1 - Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method.

AU - Murase, K

AU - Kuwabara, H

AU - Yasuhara, Y

AU - Evans, A C

AU - Gjedde, A

PY - 1996

Y1 - 1996

N2 - The authors developed a method for mapping the change in cerebral glucose utilization at two different physiological states using [(18 )F]fluorodeoxyglucose (FDC) double infection and the constrained weighted-integration method. The authors studied young normal subjects without (baseline-baseline group, n=5) and with (baseline-stimulation group, n=5) vibrotactile stimulation of the fingertips of the right hand. Dynamic scans were performed using positron emission tomography (PET) following an initial dose (the first session, 0-30 min) and an additional dose (the second session, 30-60 min). The parametric images of the net clearance of FDG from blood to brain (K*), unidirectional blood-to-brain clearance (K(1)*), and cerebral metabolic rate of glucose (CMR(glc)) of the two sessions were generated. The averaged subtraction (second minus first session) and t-statistic images were generated, which were rendered into Talairach's stereotaxic coordinates and merged with the averaged magnetic resonance imaging (MRI) image. In the baseline-baseline group, regional K*, K(1)* and CMR(glc) in the first and second sessions were strongly correlated (r(2)=0.953, 0.935, and 0.951, respectively, n=330). In the baseline-stimulation group, significant increases in these estimates were obtained in the contralateral primary somatosensory cortex (SI) (from 3.43+/-0.78 to 4.02+/-1.01 ml/100 g/min for K*, 7.85+/-1.88 to 9.09+/-1.71 ml/100 g/min for K(1)*, and 280+/-5.9 to 32.3+/-5.5 mumol/100 g/min for CMR(glc)), while there were no significant changes in the ipsilateral SI (from 3.45+/-0.83 to 359+/-0.72 ml/100 g/min for K*, 8.17+/-2.33 to 837+/-1.75 ml/100 g/min for K(1 )* and 29.5+/-8.1 to 29.1+/-8.2 mumol/100 g/mln for CMR (glc)), Significant increases in K* and CMR(glc) in the contralateral SI were clearly demonstrated in the t-statistic image. In conclusion, the proposed method allows mapping of changes in cerebral glucose utilization during physiological stimulation of the brain, and will be useful for studying the relationship between neural activity and regional cerebral glucose metabolism.

AB - The authors developed a method for mapping the change in cerebral glucose utilization at two different physiological states using [(18 )F]fluorodeoxyglucose (FDC) double infection and the constrained weighted-integration method. The authors studied young normal subjects without (baseline-baseline group, n=5) and with (baseline-stimulation group, n=5) vibrotactile stimulation of the fingertips of the right hand. Dynamic scans were performed using positron emission tomography (PET) following an initial dose (the first session, 0-30 min) and an additional dose (the second session, 30-60 min). The parametric images of the net clearance of FDG from blood to brain (K*), unidirectional blood-to-brain clearance (K(1)*), and cerebral metabolic rate of glucose (CMR(glc)) of the two sessions were generated. The averaged subtraction (second minus first session) and t-statistic images were generated, which were rendered into Talairach's stereotaxic coordinates and merged with the averaged magnetic resonance imaging (MRI) image. In the baseline-baseline group, regional K*, K(1)* and CMR(glc) in the first and second sessions were strongly correlated (r(2)=0.953, 0.935, and 0.951, respectively, n=330). In the baseline-stimulation group, significant increases in these estimates were obtained in the contralateral primary somatosensory cortex (SI) (from 3.43+/-0.78 to 4.02+/-1.01 ml/100 g/min for K*, 7.85+/-1.88 to 9.09+/-1.71 ml/100 g/min for K(1)*, and 280+/-5.9 to 32.3+/-5.5 mumol/100 g/min for CMR(glc)), while there were no significant changes in the ipsilateral SI (from 3.45+/-0.83 to 359+/-0.72 ml/100 g/min for K*, 8.17+/-2.33 to 837+/-1.75 ml/100 g/min for K(1 )* and 29.5+/-8.1 to 29.1+/-8.2 mumol/100 g/mln for CMR (glc)), Significant increases in K* and CMR(glc) in the contralateral SI were clearly demonstrated in the t-statistic image. In conclusion, the proposed method allows mapping of changes in cerebral glucose utilization during physiological stimulation of the brain, and will be useful for studying the relationship between neural activity and regional cerebral glucose metabolism.

U2 - 10.1109/42.544500

DO - 10.1109/42.544500

M3 - Journal article

C2 - 18215962

SN - 0278-0062

VL - 15

SP - 824

EP - 835

JO - I E E E Transactions on Medical Imaging

JF - I E E E Transactions on Medical Imaging

IS - 6

ER -

Mapping of change in cerebral glucose utilization using fluorine-18 fluorodeoxyglucose double injection and the constrained weighted-integration method.

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