TY - JOUR
T1 - Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis
AU - Novovic, Srdan
AU - Andersen, Anders Møller
AU - Ersbøll, Annette Kjær
AU - Jorgensen, Lars N
AU - Nielsen, Hans J
AU - Jensenius, Jens Christian
AU - Hansen, Mark Berner
PY - 2011/10
Y1 - 2011/10
N2 - Objectives: Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure. Methods: Sixty patients with AP were included. All patients were diagnosed and treated according to a standardized regimen. Blood samples were obtained immediately on admission and again on days 1, 2, and 14. Results: Both MBL (P < 0.001) and MASP-2 (P = 0.002) levels changed significantly over time, but without any significant relation to severity, multiorgan failure, or mortality. We found significantly higher levels of MBL (P = 0.04) in alcohol- than in gallstone-induced AP, but no significant difference in MASP-2 levels. Conclusions: The MBL and MASP-2 acted as acute-phase reactants, but overall, they were not markers for severity, multiorgan failure, nor for mortality in AP. Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP.
AB - Objectives: Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure. Methods: Sixty patients with AP were included. All patients were diagnosed and treated according to a standardized regimen. Blood samples were obtained immediately on admission and again on days 1, 2, and 14. Results: Both MBL (P < 0.001) and MASP-2 (P = 0.002) levels changed significantly over time, but without any significant relation to severity, multiorgan failure, or mortality. We found significantly higher levels of MBL (P = 0.04) in alcohol- than in gallstone-induced AP, but no significant difference in MASP-2 levels. Conclusions: The MBL and MASP-2 acted as acute-phase reactants, but overall, they were not markers for severity, multiorgan failure, nor for mortality in AP. Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP.
U2 - 10.1097/mpa.0b013e31821b5a72
DO - 10.1097/mpa.0b013e31821b5a72
M3 - Journal article
C2 - 21926545
SN - 0885-3177
VL - 40
SP - 1097
EP - 1102
JO - Pancreas
JF - Pancreas
IS - 7
ER -