Abstract
Traditional malaria control is in a crisis on account of chemo-resistance of Plasmodium falciparum and insecticide-resistance of the malaria mosquito. New ways to control malaria have been opened by the possibility of producing a vaccine. Several malaria proteins (e.g. CSP, gp195, Pf155/RESA, GLURP) have been sequenced and it has been shown that most of the proteins have repetitive units. Analyses of T- and B-cell epitopes show that T-cell epitopes are mainly localized to the non-conserved parts of the antigens. Repeated malaria infections, therefore, may be seen as a number of primary infections, which partly explains the very slow development of immunity to the parasite. The initial three vaccination experiments in humans did not succeed in inducing a complete protection of the individual but it showed that partial immunization is possible.
| Translated title of the contribution | Malaria vaccines, a necessity for future control of malaria. Status and future perspectives |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 152 |
| Issue number | 29 |
| Pages (from-to) | 2092-5 |
| Number of pages | 4 |
| ISSN | 0041-5782 |
| Publication status | Published - 16 Jul 1990 |
