Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials

Daniel Glinatsi; Joshua F. Baker; Merete L. Hetland; Kim Hørslev-Petersen; Bo J. Ejbjerg; Kristian Stengaard-Pedersen; Peter Junker; Torkell Ellingsen; Hanne M. Lindegaard; Ib Hansen; Tine Lottenburger; Jakob M. Møller; Lykke Ørnbjerg; Aage Vestergaard; Anne Grethe Jurik; Henrik S. Thomsen; Trine Torfing; Signe Møller-Bisgaard; Mette B. Axelsen; Mikkel Østergaard

doi:10.1136/annrheumdis-2017-211315

Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials

Daniel Glinatsi^*, Joshua F. Baker, Merete L. Hetland, Kim Hørslev-Petersen, Bo J. Ejbjerg, Kristian Stengaard-Pedersen, Peter Junker, Torkell Ellingsen, Hanne M. Lindegaard, Ib Hansen, Tine Lottenburger, Jakob M. Møller, Lykke Ørnbjerg, Aage Vestergaard, Anne Grethe Jurik, Henrik S. Thomsen, Trine Torfing, Signe Møller-Bisgaard, Mette B. Axelsen, Mikkel Østergaard

^*Corresponding author for this work

Department of Clinical Medicine

18 Citations (Scopus)

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Abstract

Objectives T o examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PRO s). Methods Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTR A/OP ERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. Results MRI inflammation, but not damage, showed statistically significant associations with HAQ, VASPtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PRO s, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patientreported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PRO s. Conclusions MRI-assessed inflammation, but not damage, in early RA wrists is associated with patientreported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand.

Original language	English
Journal	Annals of the Rheumatic Diseases
Volume	76
Issue number	10
Pages (from-to)	1707-1715
Number of pages	9
ISSN	0003-4967
DOIs	https://doi.org/10.1136/annrheumdis-2017-211315
Publication status	Published - 2017

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Glinatsi, D., Baker, J. F., Hetland, M. L., Hørslev-Petersen, K., Ejbjerg, B. J., Stengaard-Pedersen, K., Junker, P., Ellingsen, T., Lindegaard, H. M., Hansen, I., Lottenburger, T., Møller, J. M., Ørnbjerg, L., Vestergaard, A., Jurik, A. G., Thomsen, H. S., Torfing, T., Møller-Bisgaard, S., Axelsen, M. B., & Østergaard, M. (2017). Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials. Annals of the Rheumatic Diseases, 76(10), 1707-1715. https://doi.org/10.1136/annrheumdis-2017-211315

Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis : Longitudinal results from two randomised controlled trials. / Glinatsi, Daniel; Baker, Joshua F.; Hetland, Merete L. et al.

In: Annals of the Rheumatic Diseases, Vol. 76, No. 10, 2017, p. 1707-1715.

Research output: Contribution to journal › Journal article › Research › peer-review

Glinatsi, D, Baker, JF, Hetland, ML, Hørslev-Petersen, K, Ejbjerg, BJ, Stengaard-Pedersen, K, Junker, P, Ellingsen, T, Lindegaard, HM, Hansen, I, Lottenburger, T, Møller, JM, Ørnbjerg, L, Vestergaard, A, Jurik, AG, Thomsen, HS, Torfing, T, Møller-Bisgaard, S, Axelsen, MB & Østergaard, M 2017, 'Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials', Annals of the Rheumatic Diseases, vol. 76, no. 10, pp. 1707-1715. https://doi.org/10.1136/annrheumdis-2017-211315

Glinatsi D, Baker JF, Hetland ML, Hørslev-Petersen K, Ejbjerg BJ, Stengaard-Pedersen K et al. Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials. Annals of the Rheumatic Diseases. 2017;76(10):1707-1715. doi: 10.1136/annrheumdis-2017-211315

Glinatsi, Daniel ; Baker, Joshua F. ; Hetland, Merete L. et al. / Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis : Longitudinal results from two randomised controlled trials. In: Annals of the Rheumatic Diseases. 2017 ; Vol. 76, No. 10. pp. 1707-1715.

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title = "Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: Longitudinal results from two randomised controlled trials",

abstract = "Objectives T o examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PRO s). Methods Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTR A/OP ERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. Results MRI inflammation, but not damage, showed statistically significant associations with HAQ, VASPtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PRO s, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patientreported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PRO s. Conclusions MRI-assessed inflammation, but not damage, in early RA wrists is associated with patientreported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand.",

author = "Daniel Glinatsi and Baker, {Joshua F.} and Hetland, {Merete L.} and Kim H{\o}rslev-Petersen and Ejbjerg, {Bo J.} and Kristian Stengaard-Pedersen and Peter Junker and Torkell Ellingsen and Lindegaard, {Hanne M.} and Ib Hansen and Tine Lottenburger and M{\o}ller, {Jakob M.} and Lykke {\O}rnbjerg and Aage Vestergaard and Jurik, {Anne Grethe} and Thomsen, {Henrik S.} and Trine Torfing and Signe M{\o}ller-Bisgaard and Axelsen, {Mette B.} and Mikkel {\O}stergaard",

year = "2017",

doi = "10.1136/annrheumdis-2017-211315",

language = "English",

volume = "76",

pages = "1707--1715",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

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number = "10",

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TY - JOUR

T1 - Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis

T2 - Longitudinal results from two randomised controlled trials

AU - Glinatsi, Daniel

AU - Baker, Joshua F.

AU - Hetland, Merete L.

AU - Hørslev-Petersen, Kim

AU - Ejbjerg, Bo J.

AU - Stengaard-Pedersen, Kristian

AU - Junker, Peter

AU - Ellingsen, Torkell

AU - Lindegaard, Hanne M.

AU - Hansen, Ib

AU - Lottenburger, Tine

AU - Møller, Jakob M.

AU - Ørnbjerg, Lykke

AU - Vestergaard, Aage

AU - Jurik, Anne Grethe

AU - Thomsen, Henrik S.

AU - Torfing, Trine

AU - Møller-Bisgaard, Signe

AU - Axelsen, Mette B.

AU - Østergaard, Mikkel

PY - 2017

Y1 - 2017

N2 - Objectives T o examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PRO s). Methods Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTR A/OP ERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. Results MRI inflammation, but not damage, showed statistically significant associations with HAQ, VASPtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PRO s, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patientreported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PRO s. Conclusions MRI-assessed inflammation, but not damage, in early RA wrists is associated with patientreported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand.

AB - Objectives T o examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PRO s). Methods Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTR A/OP ERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. Results MRI inflammation, but not damage, showed statistically significant associations with HAQ, VASPtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PRO s, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patientreported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PRO s. Conclusions MRI-assessed inflammation, but not damage, in early RA wrists is associated with patientreported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand.

U2 - 10.1136/annrheumdis-2017-211315

DO - 10.1136/annrheumdis-2017-211315

M3 - Journal article

C2 - 28611080

AN - SCOPUS:85024892650

SN - 0003-4967

VL - 76

SP - 1707

EP - 1715

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 10

ER -