Lymphadenectomy in surgical stage I epithelial ovarian cancer

Olivia Svolgaard; Ojvind Lidegaard; Marie Louise S Nielsen; Lotte Nedergaard; Berit J Mosgaard; Marianne Lidang; Ole Mogensen; Kirsten Kock; Jan Blaakaer; Estrid Staehr; Erik S Andersen; Anni Grove; Claus Høgdall

doi:10.1111/aogs.12322

Lymphadenectomy in surgical stage I epithelial ovarian cancer

Olivia Svolgaard, Ojvind Lidegaard, Marie Louise S Nielsen, Lotte Nedergaard, Berit J Mosgaard, Marianne Lidang, Ole Mogensen, Kirsten Kock, Jan Blaakaer, Estrid Staehr, Erik S Andersen, Anni Grove, Claus Høgdall

Department of Clinical Medicine

10 Citations (Scopus)

Abstract

OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.

DESIGN: A prospective nationwide case-only study.

SETTING: Denmark 2005-2011.

SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).

METHOD: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.

MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.

RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5-year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.

CONCLUSION: Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.

Original language	English
Journal	Acta Obstetrica et Gynecologica
Volume	93
Issue number	3
Pages (from-to)	256-260
Number of pages	5
ISSN	0001-6349
DOIs	https://doi.org/10.1111/aogs.12322
Publication status	Published - Mar 2014

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Denmark
Female
Humans
Lymph Node Excision
Lymph Nodes
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Prospective Studies
Registries
Survival Analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

@article{f75c99286e314f999a30e70872329574,

title = "Lymphadenectomy in surgical stage I epithelial ovarian cancer",

abstract = "OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.DESIGN: A prospective nationwide case-only study.SETTING: Denmark 2005-2011.SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).METHOD: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5-year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.CONCLUSION: Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Denmark, Female, Humans, Lymph Node Excision, Lymph Nodes, Lymphatic Metastasis, Middle Aged, Neoplasm Staging, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Prospective Studies, Registries, Survival Analysis",

author = "Olivia Svolgaard and Ojvind Lidegaard and Nielsen, {Marie Louise S} and Lotte Nedergaard and Mosgaard, {Berit J} and Marianne Lidang and Ole Mogensen and Kirsten Kock and Jan Blaakaer and Estrid Staehr and Andersen, {Erik S} and Anni Grove and Claus H{\o}gdall",

note = "{\textcopyright} 2013 Nordic Federation of Societies of Obstetrics and Gynecology.",

year = "2014",

month = mar,

doi = "10.1111/aogs.12322",

language = "English",

volume = "93",

pages = "256--260",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "GrupoSaned",

number = "3",

}

TY - JOUR

T1 - Lymphadenectomy in surgical stage I epithelial ovarian cancer

AU - Svolgaard, Olivia

AU - Lidegaard, Ojvind

AU - Nielsen, Marie Louise S

AU - Nedergaard, Lotte

AU - Mosgaard, Berit J

AU - Lidang, Marianne

AU - Mogensen, Ole

AU - Kock, Kirsten

AU - Blaakaer, Jan

AU - Staehr, Estrid

AU - Andersen, Erik S

AU - Grove, Anni

AU - Høgdall, Claus

PY - 2014/3

Y1 - 2014/3

N2 - OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.DESIGN: A prospective nationwide case-only study.SETTING: Denmark 2005-2011.SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).METHOD: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5-year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.CONCLUSION: Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.

AB - OBJECTIVE: To identify the extent of lymphadenectomy performed in women presenting with epithelial ovarian cancer macroscopically confined to the ovary. Furthermore, the effect of lymphadenectomy on overall survival is evaluated.DESIGN: A prospective nationwide case-only study.SETTING: Denmark 2005-2011.SAMPLE: All women registered in the nationwide Danish Gynecologic Cancer Database from 1 January 2005 to 1 May 2011, presenting with a tumor macroscopically confined to the ovary without visible evidence of abdominal spread at the time of the initial exploration (surgical stage I).METHOD: Descriptive and survival analyses of data from Danish Gynecologic Cancer Database.MAIN OUTCOME MEASURES: The annual proportion of women with surgical stage I disease who received lymphadenectomy and the survival in the two groups.RESULTS: Of 2361 women with epithelial ovarian cancer, 627 were identified with surgical stage I. Lymphadenectomy was performed in 216 women (34%) of whom 13 (6%) had lymph node metastases. At 5-year follow up 85% remained alive in the lymphadenectomy group compared with 80% in the control group (p = 0.064). The lymphadenectomy fraction increased from 24% in 2005 to 55% in 2011. When univariate and multivariate analyses were conducted only an insignificant difference in the survival probability was found between lymphadenectomy and no lymphadenectomy in women presenting with tumor macroscopically confined to the ovary.CONCLUSION: Although increasing, the number of women with surgical stage I disease in Denmark who receive lymphadenectomy remains low, but this did not seem to make a difference to survival.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Female

KW - Humans

KW - Lymph Node Excision

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Neoplasm Staging

KW - Neoplasms, Glandular and Epithelial

KW - Ovarian Neoplasms

KW - Prospective Studies

KW - Registries

KW - Survival Analysis

U2 - 10.1111/aogs.12322

DO - 10.1111/aogs.12322

M3 - Journal article

C2 - 24447203

SN - 0001-6349

VL - 93

SP - 256

EP - 260

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 3

ER -

Lymphadenectomy in surgical stage I epithelial ovarian cancer

Abstract

Keywords

UN SDGs

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