Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control

TY - JOUR

T1 - Lyme disease ecology in a changing world

T2 - consensus, uncertainty and critical gaps for improving control

AU - Kilpatrick, A. Marm

AU - Dobson, Andrew D.M.

AU - Levi, Taal

AU - Salkeld, Daniel J.

AU - Swei, Andrea

AU - Ginsberg, Howard S.

AU - Kjemtrup, Anne

AU - Padgett, Kerry A.

AU - Jensen, Per Moestrup

AU - Fish, Durland

AU - Ogden, Nick H.

AU - Diuk-Wasser, Maria A.

N1 - © 2017 The Author(s).

PY - 2017/6/5

Y1 - 2017/6/5

N2 - Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi. Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host–vector-borne zoonotic disease.

AB - Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi. Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host–vector-borne zoonotic disease.

KW - Journal Article

KW - Review

U2 - 10.1098/rstb.2016.0117

DO - 10.1098/rstb.2016.0117

M3 - Review

C2 - 28438910

SN - 0962-8436

VL - 372

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

IS - 1722

M1 - 20160117

ER -