LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Anne-Sophie Lequarré; Leif Andersson; Catherine André; Merete Fredholm; Christophe Hitte; Tosso Leeb; Hannes Lohi; Kerstin Lindblad-Toh; Michel Georges

doi:10.1016/j.tvjl.2011.06.013

LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Anne-Sophie Lequarré, Leif Andersson, Catherine André, Merete Fredholm, Christophe Hitte, Tosso Leeb, Hannes Lohi, Kerstin Lindblad-Toh, Michel Georges

73 Citations (Scopus)

Abstract

The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.

Original language	English
Journal	The Veterinary Journal
Volume	189
Issue number	2
Pages (from-to)	155-159
Number of pages	5
ISSN	1090-0233
DOIs	https://doi.org/10.1016/j.tvjl.2011.06.013
Publication status	Published - Aug 2011

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10.1016/j.tvjl.2011.06.013

Cite this

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title = "LUPA: a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs",

abstract = "The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.",

author = "Anne-Sophie Lequarr{\'e} and Leif Andersson and Catherine Andr{\'e} and Merete Fredholm and Christophe Hitte and Tosso Leeb and Hannes Lohi and Kerstin Lindblad-Toh and Michel Georges",

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AU - Lequarré, Anne-Sophie

AU - Andersson, Leif

AU - André, Catherine

AU - Fredholm, Merete

AU - Hitte, Christophe

AU - Leeb, Tosso

AU - Lohi, Hannes

AU - Lindblad-Toh, Kerstin

AU - Georges, Michel

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