TY - JOUR
T1 - Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men
T2 - Results from the Danish Blood Donor Study (DBDS)
AU - Kaspersen, Kathrine Agergård
AU - Dinh, Khoa Manh
AU - Erikstrup, Lise Tornvig
AU - Burgdorf, Kristoffer Sølvsten
AU - Pedersen, Ole Birger
AU - Sørensen, Erik
AU - Petersen, Mikkel Steen
AU - Hjalgrim, Henrik
AU - Rostgaard, Klaus
AU - Nielsen, Kaspar Rene
AU - Ullum, Henrik
AU - Erikstrup, Christian
PY - 2016/10
Y1 - 2016/10
N2 - INTRODUCTION: The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.METHODS: We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.RESULTS: During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.CONCLUSIONS: In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
AB - INTRODUCTION: The aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.METHODS: We included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.RESULTS: During 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.CONCLUSIONS: In a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
KW - Journal Article
U2 - 10.1371/journal.pone.0164220
DO - 10.1371/journal.pone.0164220
M3 - Journal article
C2 - 27701463
SN - 1932-6203
VL - 11
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 10
M1 - e0164220
ER -