Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

Hans Rasmussen; Vibe G Frokjaer; Rikke W Hilker; Jacob Madsen; Simon Anhøj; Bob Oranje; Lars H Pinborg; Birte Glenthøj; Gitte M Knudsen

doi:10.1016/j.euroneuro.2016.04.008

Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

Hans Rasmussen, Vibe G Frokjaer, Rikke W Hilker, Jacob Madsen, Simon Anhøj, Bob Oranje, Lars H Pinborg, Birte Glenthøj, Gitte M Knudsen

Department of Clinical Medicine

13 Citations (Scopus)

Abstract

Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.

Original language	English
Journal	European Neuropsychopharmacology
Volume	26
Issue number	7
Pages (from-to)	1248-50
Number of pages	3
ISSN	0924-977X
DOIs	https://doi.org/10.1016/j.euroneuro.2016.04.008
Publication status	Published - 1 Jul 2016

Keywords

Journal Article

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10.1016/j.euroneuro.2016.04.008

Cite this

@article{579a57cd04d04dcfb162450c745b59a1,

title = "Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?",

abstract = "Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-na{\"i}ve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.",

keywords = "Journal Article",

author = "Hans Rasmussen and Frokjaer, {Vibe G} and Hilker, {Rikke W} and Jacob Madsen and Simon Anh{\o}j and Bob Oranje and Pinborg, {Lars H} and Birte Glenth{\o}j and Knudsen, {Gitte M}",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.euroneuro.2016.04.008",

language = "English",

volume = "26",

pages = "1248--50",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",