Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache

Kim Lindelof; Kerstin Jung; Jens Ellrich; Rigmor Jensen; Lars Bendtsen

doi:10.1177/0333102409354783

Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache

Kim Lindelof, Kerstin Jung, Jens Ellrich, Rigmor Jensen, Lars Bendtsen

8 Citations (Scopus)

Abstract

Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term depression (LTD), in patients with chronic tension-type headache (CTTH). Twenty CTTH patients and 20 healthy volunteers were exposed to 20 min LFS (1 Hz) to the forehead. LTD was measured as a decrease in pain response to electrical stimulation in a 1-h post-LFS period following LFS. The LFS induced a significant and stable inhibition of pain (LTD) both in patients with CTTH (post-LFS average decrease in pain rating: 19.6 ± 3.9%, all P < 0.005, Holm-Sidak) and in healthy controls (30.1 ± 5.0%, all P < 0.001, Holm-Sidak). During the LFS period, the pain ratings decreased consistently in both groups. In conclusion, a significant and stable pain inhibition (LTD) can be induced in CTTH patients by LFS.

Original language	English
Journal	Cephalalgia
Volume	30
Issue number	7
Pages (from-to)	860-867
Number of pages	7
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102409354783
Publication status	Published - Jul 2010

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title = "Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache",

abstract = "Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term depression (LTD), in patients with chronic tension-type headache (CTTH). Twenty CTTH patients and 20 healthy volunteers were exposed to 20 min LFS (1 Hz) to the forehead. LTD was measured as a decrease in pain response to electrical stimulation in a 1-h post-LFS period following LFS. The LFS induced a significant and stable inhibition of pain (LTD) both in patients with CTTH (post-LFS average decrease in pain rating: 19.6 ± 3.9%, all P < 0.005, Holm-Sidak) and in healthy controls (30.1 ± 5.0%, all P < 0.001, Holm-Sidak). During the LFS period, the pain ratings decreased consistently in both groups. In conclusion, a significant and stable pain inhibition (LTD) can be induced in CTTH patients by LFS.",

author = "Kim Lindelof and Kerstin Jung and Jens Ellrich and Rigmor Jensen and Lars Bendtsen",

note = "10.1177/0333102409354783",

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T1 - Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache

AU - Lindelof, Kim

AU - Jung, Kerstin

AU - Ellrich, Jens

AU - Jensen, Rigmor

AU - Bendtsen, Lars

N1 - 10.1177/0333102409354783

PY - 2010/7

Y1 - 2010/7

N2 - Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term depression (LTD), in patients with chronic tension-type headache (CTTH). Twenty CTTH patients and 20 healthy volunteers were exposed to 20 min LFS (1 Hz) to the forehead. LTD was measured as a decrease in pain response to electrical stimulation in a 1-h post-LFS period following LFS. The LFS induced a significant and stable inhibition of pain (LTD) both in patients with CTTH (post-LFS average decrease in pain rating: 19.6 ± 3.9%, all P < 0.005, Holm-Sidak) and in healthy controls (30.1 ± 5.0%, all P < 0.001, Holm-Sidak). During the LFS period, the pain ratings decreased consistently in both groups. In conclusion, a significant and stable pain inhibition (LTD) can be induced in CTTH patients by LFS.

AB - Repetitive low-frequency electrical stimulation (LFS) induces pain inhibition in healthy volunteers and in animals, but it is unknown whether it has an analgesic effect in patients with headache. The aim of this study was to investigate if LFS could induce prolonged pain inhibition, called long-term depression (LTD), in patients with chronic tension-type headache (CTTH). Twenty CTTH patients and 20 healthy volunteers were exposed to 20 min LFS (1 Hz) to the forehead. LTD was measured as a decrease in pain response to electrical stimulation in a 1-h post-LFS period following LFS. The LFS induced a significant and stable inhibition of pain (LTD) both in patients with CTTH (post-LFS average decrease in pain rating: 19.6 ± 3.9%, all P < 0.005, Holm-Sidak) and in healthy controls (30.1 ± 5.0%, all P < 0.001, Holm-Sidak). During the LFS period, the pain ratings decreased consistently in both groups. In conclusion, a significant and stable pain inhibition (LTD) can be induced in CTTH patients by LFS.

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DO - 10.1177/0333102409354783

M3 - Journal article

SN - 0800-1952

VL - 30

SP - 860

EP - 867

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

IS - 7

ER -

Low-frequency electrical stimulation induces long-term depression in patients with chronic tension-type headache

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