Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

Cecilia Magnusson; Maryna Mezhybovska; Ester LÃ¶rinc; Eva Fernebro; Mef Nilbert; Anita SjÃ¶lander; Cecilia Magnusson; Maryna Mezhybovska; Ester Lörinc; Eva Fernebro; Mef Nilbert; Anita Sjölander

doi:10.1016/j.ejca.2009.12.022

Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

Cecilia Magnusson, Maryna Mezhybovska, Ester LÃ¶rinc, Eva Fernebro, Mef Nilbert, Anita SjÃ¶lander, Cecilia Magnusson, Maryna Mezhybovska, Ester Lörinc, Eva Fernebro, Mef Nilbert, Anita Sjölander

53 Citations (Scopus)

Abstract

Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT₁R, and cell differentiation via the CysLT₂R. These results prompted us to investigate the significance of CysLT₁R and CysLT₂R expression in colorectal cancer tissue for patient survival. The CysLT₁R, CysLT₂R, β-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT₁R is associated with a poor prognosis, whereas high nuclear expression of CysLT₂R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT₁R but low CysLT₂R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT₁R but high CysLT₂R nuclear expression had the best survival expectancy. Interestingly, β-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT₁R nuclear expression, an elevated β-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.

Translated title of the contribution	Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer
Original language	English
Journal	European Journal of Cancer
Volume	46
Issue number	4
Pages (from-to)	826-35
Number of pages	9
ISSN	0959-8049
DOIs	https://doi.org/10.1016/j.ejca.2009.12.022
Publication status	Published - Mar 2010

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Magnusson, C., Mezhybovska, M., LÃ¶rinc, E., Fernebro, E., Nilbert, M., SjÃ¶lander, A., Magnusson, C., Mezhybovska, M., Lörinc, E., Fernebro, E., Nilbert, M., & Sjölander, A. (2010). Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer. European Journal of Cancer, 46(4), 826-35. https://doi.org/10.1016/j.ejca.2009.12.022

Magnusson, C, Mezhybovska, M, LÃ¶rinc, E, Fernebro, E, Nilbert, M, SjÃ¶lander, A, Magnusson, C, Mezhybovska, M, Lörinc, E, Fernebro, E, Nilbert, M & Sjölander, A 2010, 'Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer', European Journal of Cancer, vol. 46, no. 4, pp. 826-35. https://doi.org/10.1016/j.ejca.2009.12.022

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title = "Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer",

abstract = "Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT1R, and cell differentiation via the CysLT2R. These results prompted us to investigate the significance of CysLT1R and CysLT2R expression in colorectal cancer tissue for patient survival. The CysLT1R, CysLT2R, β-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT1R is associated with a poor prognosis, whereas high nuclear expression of CysLT2R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT1R but low CysLT2R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT1R but high CysLT2R nuclear expression had the best survival expectancy. Interestingly, β-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT1R nuclear expression, an elevated β-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.",

author = "Cecilia Magnusson and Maryna Mezhybovska and Ester L{\~A}¶rinc and Eva Fernebro and Mef Nilbert and Anita Sj{\~A}¶lander and Cecilia Magnusson and Maryna Mezhybovska and Ester L{\"o}rinc and Eva Fernebro and Mef Nilbert and Anita Sj{\"o}lander",

year = "2010",

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doi = "10.1016/j.ejca.2009.12.022",

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T1 - Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

AU - Magnusson, Cecilia

AU - Mezhybovska, Maryna

AU - LÃ¶rinc, Ester

AU - Fernebro, Eva

AU - Nilbert, Mef

AU - SjÃ¶lander, Anita

AU - Magnusson, Cecilia

AU - Mezhybovska, Maryna

AU - Lörinc, Ester

AU - Fernebro, Eva

AU - Nilbert, Mef

AU - Sjölander, Anita

PY - 2010/3

Y1 - 2010/3

N2 - Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT1R, and cell differentiation via the CysLT2R. These results prompted us to investigate the significance of CysLT1R and CysLT2R expression in colorectal cancer tissue for patient survival. The CysLT1R, CysLT2R, β-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT1R is associated with a poor prognosis, whereas high nuclear expression of CysLT2R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT1R but low CysLT2R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT1R but high CysLT2R nuclear expression had the best survival expectancy. Interestingly, β-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT1R nuclear expression, an elevated β-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.

AB - Colorectal cancer is the third most common cancer type in the Western world. In search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT1R, and cell differentiation via the CysLT2R. These results prompted us to investigate the significance of CysLT1R and CysLT2R expression in colorectal cancer tissue for patient survival. The CysLT1R, CysLT2R, β-catenin and Bcl-xL protein expression levels were evaluated by immunohistochemistry in a tissue microarray of 329 colorectal patients. We found that high nuclear expression of CysLT1R is associated with a poor prognosis, whereas high nuclear expression of CysLT2R is associated with a good prognosis. We also observed that patients with colorectal tumours characterised by high CysLT1R but low CysLT2R nuclear expression had the lowest survival expectancy, whereas patients with colorectal tumours characterised by low CysLT1R but high CysLT2R nuclear expression had the best survival expectancy. Interestingly, β-catenin as a single prognostic marker did not exhibit any prognostic value. However, in patients with tumours characterised by a high CysLT1R nuclear expression, an elevated β-catenin nuclear expression had a significantly prognostic value. In conclusion these data indicate that nuclear expressions of CysLTRs are potential prognostic indicators of colorectal cancer.

U2 - 10.1016/j.ejca.2009.12.022

DO - 10.1016/j.ejca.2009.12.022

M3 - Journal article

C2 - 20064706

SN - 0959-8049

VL - 46

SP - 826

EP - 835

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 4

ER -

Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer

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