Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study

Casper P Hagen; Sonja Vestergaard; Anders Juul; Niels Erik Skakkebæk; Anna-Maria Andersson; Katharina M Main; Niels Henrik Hjøllund; Erik Ernst; Jens Peter Bonde; Richard A Anderson; Tina Kold Jensen

doi:10.1016/j.fertnstert.2012.08.008

Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study

Casper P Hagen, Sonja Vestergaard, Anders Juul, Niels Erik Skakkebæk, Anna-Maria Andersson, Katharina M Main, Niels Henrik Hjøllund, Erik Ernst, Jens Peter Bonde, Richard A Anderson, Tina Kold Jensen

106 Citations (Scopus)

Abstract

Objective: To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. Design: Prospective cohort study. Setting: General community. Patient(s): A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for six menstrual cycles. Intervention(s): None. Main Outcome Measure(s): Fecundability was evaluated by the monthly probability of conceiving (i.e., fecundability ratio [FR]). In addition, circulating levels of LH, FSH, T, and sex hormone-binding globulin (SHBG) were evaluated in 158 of 186 women. Result(s): Fifty-nine percent of couples conceived during the study period. Compared to the reference group of women with medium AMH (AMH quintiles 2-4), fecundability did not differ significantly in women with low AMH (AMH quintile 1) (FR 0.81; 95% confidence interval [CI] 0.44-1.40). In contrast, women with high AMH (AMH quintile 5) had reduced fecundability (FR 0.62; 95% CI 0.39-0.99) after adjustment for covariates (woman's age, body mass index [BMI], smoking, diseases affecting fecundability, and oligozoospermia). Irregular menstrual cycles were more prevalent in women with high AMH compared with women with low or medium AMH levels, and they had higher levels of LH (geometric mean: 8.4 vs. 5.3 IU/L) and LH:FSH ratio (2.4 vs. 1.8). After exclusion of women with irregular cycles, women with high AMH still had reduced fecundability (FR 0.48; 95% CI 0.27-0.85) and elevated LH:FSH ratio (2.4 vs. 1.7). Conclusion(s): Low AMH in healthy women in their mid-20s did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH.

Original language	English
Journal	Fertility and Sterility
Volume	98
Issue number	6
Pages (from-to)	1602-8.e2
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2012.08.008
Publication status	Published - Dec 2012

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Hagen, C. P., Vestergaard, S., Juul, A., Skakkebæk, N. E., Andersson, A-M., Main, K. M., Hjøllund, N. H., Ernst, E., Bonde, J. P., Anderson, R. A., & Jensen, T. K. (2012). Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study. Fertility and Sterility, 98(6), 1602-8.e2. https://doi.org/10.1016/j.fertnstert.2012.08.008

Hagen, CP, Vestergaard, S, Juul, A , Skakkebæk, NE, Andersson, A-M, Main, KM, Hjøllund, NH, Ernst, E, Bonde, JP, Anderson, RA & Jensen, TK 2012, 'Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study', Fertility and Sterility, vol. 98, no. 6, pp. 1602-8.e2. https://doi.org/10.1016/j.fertnstert.2012.08.008

@article{2cfe470115664fcbbbf201f81602985b,

title = "Low concentration of circulating antim{\"u}llerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study",

abstract = "Objective: To evaluate whether circulating levels of antim{\"u}llerian hormone (AMH) predict fecundability in young healthy women. Design: Prospective cohort study. Setting: General community. Patient(s): A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for six menstrual cycles. Intervention(s): None. Main Outcome Measure(s): Fecundability was evaluated by the monthly probability of conceiving (i.e., fecundability ratio [FR]). In addition, circulating levels of LH, FSH, T, and sex hormone-binding globulin (SHBG) were evaluated in 158 of 186 women. Result(s): Fifty-nine percent of couples conceived during the study period. Compared to the reference group of women with medium AMH (AMH quintiles 2-4), fecundability did not differ significantly in women with low AMH (AMH quintile 1) (FR 0.81; 95% confidence interval [CI] 0.44-1.40). In contrast, women with high AMH (AMH quintile 5) had reduced fecundability (FR 0.62; 95% CI 0.39-0.99) after adjustment for covariates (woman's age, body mass index [BMI], smoking, diseases affecting fecundability, and oligozoospermia). Irregular menstrual cycles were more prevalent in women with high AMH compared with women with low or medium AMH levels, and they had higher levels of LH (geometric mean: 8.4 vs. 5.3 IU/L) and LH:FSH ratio (2.4 vs. 1.8). After exclusion of women with irregular cycles, women with high AMH still had reduced fecundability (FR 0.48; 95% CI 0.27-0.85) and elevated LH:FSH ratio (2.4 vs. 1.7). Conclusion(s): Low AMH in healthy women in their mid-20s did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH.",

author = "Hagen, {Casper P} and Sonja Vestergaard and Anders Juul and Skakkeb{\ae}k, {Niels Erik} and Anna-Maria Andersson and Main, {Katharina M} and Hj{\o}llund, {Niels Henrik} and Erik Ernst and Bonde, {Jens Peter} and Anderson, {Richard A} and Jensen, {Tina Kold}",

year = "2012",

month = dec,

doi = "10.1016/j.fertnstert.2012.08.008",

language = "English",

volume = "98",

pages = "1602--8.e2",

journal = "Sexuality, Reproduction and Menopause",

issn = "1546-2501",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women

T2 - a prospective cohort study

AU - Hagen, Casper P

AU - Vestergaard, Sonja

AU - Juul, Anders

AU - Skakkebæk, Niels Erik

AU - Andersson, Anna-Maria

AU - Main, Katharina M

AU - Hjøllund, Niels Henrik

AU - Ernst, Erik

AU - Bonde, Jens Peter

AU - Anderson, Richard A

AU - Jensen, Tina Kold

PY - 2012/12

Y1 - 2012/12

N2 - Objective: To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. Design: Prospective cohort study. Setting: General community. Patient(s): A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for six menstrual cycles. Intervention(s): None. Main Outcome Measure(s): Fecundability was evaluated by the monthly probability of conceiving (i.e., fecundability ratio [FR]). In addition, circulating levels of LH, FSH, T, and sex hormone-binding globulin (SHBG) were evaluated in 158 of 186 women. Result(s): Fifty-nine percent of couples conceived during the study period. Compared to the reference group of women with medium AMH (AMH quintiles 2-4), fecundability did not differ significantly in women with low AMH (AMH quintile 1) (FR 0.81; 95% confidence interval [CI] 0.44-1.40). In contrast, women with high AMH (AMH quintile 5) had reduced fecundability (FR 0.62; 95% CI 0.39-0.99) after adjustment for covariates (woman's age, body mass index [BMI], smoking, diseases affecting fecundability, and oligozoospermia). Irregular menstrual cycles were more prevalent in women with high AMH compared with women with low or medium AMH levels, and they had higher levels of LH (geometric mean: 8.4 vs. 5.3 IU/L) and LH:FSH ratio (2.4 vs. 1.8). After exclusion of women with irregular cycles, women with high AMH still had reduced fecundability (FR 0.48; 95% CI 0.27-0.85) and elevated LH:FSH ratio (2.4 vs. 1.7). Conclusion(s): Low AMH in healthy women in their mid-20s did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH.

AB - Objective: To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. Design: Prospective cohort study. Setting: General community. Patient(s): A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for six menstrual cycles. Intervention(s): None. Main Outcome Measure(s): Fecundability was evaluated by the monthly probability of conceiving (i.e., fecundability ratio [FR]). In addition, circulating levels of LH, FSH, T, and sex hormone-binding globulin (SHBG) were evaluated in 158 of 186 women. Result(s): Fifty-nine percent of couples conceived during the study period. Compared to the reference group of women with medium AMH (AMH quintiles 2-4), fecundability did not differ significantly in women with low AMH (AMH quintile 1) (FR 0.81; 95% confidence interval [CI] 0.44-1.40). In contrast, women with high AMH (AMH quintile 5) had reduced fecundability (FR 0.62; 95% CI 0.39-0.99) after adjustment for covariates (woman's age, body mass index [BMI], smoking, diseases affecting fecundability, and oligozoospermia). Irregular menstrual cycles were more prevalent in women with high AMH compared with women with low or medium AMH levels, and they had higher levels of LH (geometric mean: 8.4 vs. 5.3 IU/L) and LH:FSH ratio (2.4 vs. 1.8). After exclusion of women with irregular cycles, women with high AMH still had reduced fecundability (FR 0.48; 95% CI 0.27-0.85) and elevated LH:FSH ratio (2.4 vs. 1.7). Conclusion(s): Low AMH in healthy women in their mid-20s did not predict reduced fecundability. Even after exclusion of women with irregular cycles, the probability of conceiving was reduced in women with high AMH.

U2 - 10.1016/j.fertnstert.2012.08.008

DO - 10.1016/j.fertnstert.2012.08.008

M3 - Journal article

C2 - 22959460

SN - 1546-2501

VL - 98

SP - 1602-8.e2

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

IS - 6

ER -

Low concentration of circulating antimüllerian hormone is not predictive of reduced fecundability in young healthy women: a prospective cohort study

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