Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

K Pilgaard; K Færch; B Carstensen; P Poulsen; C Pisinger; Oluf Pedersen; D R Witte; T Hansen; Torben Jørgensen; A Vaag

doi:10.1007/s00125-010-1917-3

Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

K Pilgaard, K Færch, B Carstensen, P Poulsen, C Pisinger, Oluf Pedersen, D R Witte, T Hansen, Torben Jørgensen, A Vaag

68 Citations (Scopus)

Abstract

Aims/hypothesis: We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237). Methods: Information about size at birth and prematurity was identified from original midwife records in 4,744 middle-aged Danes. Type 2 diabetes status, insulin sensitivity (Matsuda index) and beta cell function (disposition index) were assessed using a 75 g oral glucose tolerance test. Participants born prematurely were compared with a group of at-term participants born small for gestational age. Results: An increase in birthweight of 1 kg was associated with a 51% (OR 0.49, 95% CI 0.35-0.69) reduced risk of type 2 diabetes. Ponderal index, reflecting thinness at birth, was associated with type 2 diabetes to the same extent as birthweight. The prevalence of type 2 diabetes was increased to a similar degree in participants born prematurely and participants born small for gestational age, although the former had a higher ponderal index at birth. In addition, birthweight z-scores, reflecting fetal growth rate, were unrelated to the risk of type 2 diabetes and to other measures of glucose regulation in participants born prematurely. While low birthweight was inversely associated with insulin sensitivity and beta cell function, prematurity was associated solely with decreased insulin sensitivity. Conclusions/interpretation: While the association between birthweight and risk of type 2 diabetes is mediated via combined effects on beta cell function and insulin sensitivity, prematurity seems to influence risk of type 2 diabetes via attenuated insulin sensitivity only and independently of fetal growth rates.

Original language	English
Journal	Diabetologia
Volume	53
Issue number	12
Pages (from-to)	2526-30
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-010-1917-3
Publication status	Published - 1 Dec 2010

Keywords

Adult
Birth Weight
Denmark
Diabetes Mellitus, Type 2
Female
Glucose Intolerance
Humans
Infant, Low Birth Weight
Infant, Newborn
Insulin Resistance
Insulin-Secreting Cells
Middle Aged
Pregnancy
Premature Birth
Random Allocation
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-010-1917-3

Cite this

@article{a979dc07ffca4f97ac99830523ff2f45,

title = "Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes",

abstract = "Aims/hypothesis: We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237). Methods: Information about size at birth and prematurity was identified from original midwife records in 4,744 middle-aged Danes. Type 2 diabetes status, insulin sensitivity (Matsuda index) and beta cell function (disposition index) were assessed using a 75 g oral glucose tolerance test. Participants born prematurely were compared with a group of at-term participants born small for gestational age. Results: An increase in birthweight of 1 kg was associated with a 51% (OR 0.49, 95% CI 0.35-0.69) reduced risk of type 2 diabetes. Ponderal index, reflecting thinness at birth, was associated with type 2 diabetes to the same extent as birthweight. The prevalence of type 2 diabetes was increased to a similar degree in participants born prematurely and participants born small for gestational age, although the former had a higher ponderal index at birth. In addition, birthweight z-scores, reflecting fetal growth rate, were unrelated to the risk of type 2 diabetes and to other measures of glucose regulation in participants born prematurely. While low birthweight was inversely associated with insulin sensitivity and beta cell function, prematurity was associated solely with decreased insulin sensitivity. Conclusions/interpretation: While the association between birthweight and risk of type 2 diabetes is mediated via combined effects on beta cell function and insulin sensitivity, prematurity seems to influence risk of type 2 diabetes via attenuated insulin sensitivity only and independently of fetal growth rates.",

keywords = "Adult, Birth Weight, Denmark, Diabetes Mellitus, Type 2, Female, Glucose Intolerance, Humans, Infant, Low Birth Weight, Infant, Newborn, Insulin Resistance, Insulin-Secreting Cells, Middle Aged, Pregnancy, Premature Birth, Random Allocation, Risk Factors",

author = "K Pilgaard and K F{\ae}rch and B Carstensen and P Poulsen and C Pisinger and Oluf Pedersen and Witte, {D R} and T Hansen and Torben J{\o}rgensen and A Vaag",

year = "2010",

month = dec,

day = "1",

doi = "10.1007/s00125-010-1917-3",

language = "English",

volume = "53",

pages = "2526--30",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "12",

}

TY - JOUR

T1 - Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

AU - Pilgaard, K

AU - Færch, K

AU - Carstensen, B

AU - Poulsen, P

AU - Pisinger, C

AU - Pedersen, Oluf

AU - Witte, D R

AU - Hansen, T

AU - Jørgensen, Torben

AU - Vaag, A

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Aims/hypothesis: We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237). Methods: Information about size at birth and prematurity was identified from original midwife records in 4,744 middle-aged Danes. Type 2 diabetes status, insulin sensitivity (Matsuda index) and beta cell function (disposition index) were assessed using a 75 g oral glucose tolerance test. Participants born prematurely were compared with a group of at-term participants born small for gestational age. Results: An increase in birthweight of 1 kg was associated with a 51% (OR 0.49, 95% CI 0.35-0.69) reduced risk of type 2 diabetes. Ponderal index, reflecting thinness at birth, was associated with type 2 diabetes to the same extent as birthweight. The prevalence of type 2 diabetes was increased to a similar degree in participants born prematurely and participants born small for gestational age, although the former had a higher ponderal index at birth. In addition, birthweight z-scores, reflecting fetal growth rate, were unrelated to the risk of type 2 diabetes and to other measures of glucose regulation in participants born prematurely. While low birthweight was inversely associated with insulin sensitivity and beta cell function, prematurity was associated solely with decreased insulin sensitivity. Conclusions/interpretation: While the association between birthweight and risk of type 2 diabetes is mediated via combined effects on beta cell function and insulin sensitivity, prematurity seems to influence risk of type 2 diabetes via attenuated insulin sensitivity only and independently of fetal growth rates.

AB - Aims/hypothesis: We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237). Methods: Information about size at birth and prematurity was identified from original midwife records in 4,744 middle-aged Danes. Type 2 diabetes status, insulin sensitivity (Matsuda index) and beta cell function (disposition index) were assessed using a 75 g oral glucose tolerance test. Participants born prematurely were compared with a group of at-term participants born small for gestational age. Results: An increase in birthweight of 1 kg was associated with a 51% (OR 0.49, 95% CI 0.35-0.69) reduced risk of type 2 diabetes. Ponderal index, reflecting thinness at birth, was associated with type 2 diabetes to the same extent as birthweight. The prevalence of type 2 diabetes was increased to a similar degree in participants born prematurely and participants born small for gestational age, although the former had a higher ponderal index at birth. In addition, birthweight z-scores, reflecting fetal growth rate, were unrelated to the risk of type 2 diabetes and to other measures of glucose regulation in participants born prematurely. While low birthweight was inversely associated with insulin sensitivity and beta cell function, prematurity was associated solely with decreased insulin sensitivity. Conclusions/interpretation: While the association between birthweight and risk of type 2 diabetes is mediated via combined effects on beta cell function and insulin sensitivity, prematurity seems to influence risk of type 2 diabetes via attenuated insulin sensitivity only and independently of fetal growth rates.

KW - Adult

KW - Birth Weight

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Intolerance

KW - Humans

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Middle Aged

KW - Pregnancy

KW - Premature Birth

KW - Random Allocation

KW - Risk Factors

U2 - 10.1007/s00125-010-1917-3

DO - 10.1007/s00125-010-1917-3

M3 - Journal article

C2 - 20859612

SN - 0012-186X

VL - 53

SP - 2526

EP - 2530

JO - Diabetologia

JF - Diabetologia

IS - 12

ER -

Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this