Low and high body mass index in hidradenitis suppurativa patients-different subtypes?

TY - JOUR

T1 - Low and high body mass index in hidradenitis suppurativa patients-different subtypes?

AU - Theut Riis, P

AU - Saunte, D M

AU - Benhadou, F

AU - Del Marmol, V

AU - Guillem, P

AU - El-Domyati, M

AU - Abdel-Wahab, H

AU - Antoniou, C

AU - Dessinioti, C

AU - Gürer, M A

AU - Beksaç, B

AU - Szepietowski, J C

AU - Matusiak, L

AU - Emtestam, L

AU - Lapins, J

AU - Riad, H

AU - Doss, N

AU - Massa, A F

AU - Hamzavi, I

AU - Nicholson, C

AU - Dolenc-Voljc, M

AU - Kim, K H

AU - Ohn, J

AU - Zouboulis, C C

AU - Karagiannidis, I

AU - Mokos, Z B

AU - Durinec, P

AU - Jemec, G B E

N1 - © 2017 European Academy of Dermatology and Venereology.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.

AB - Introduction: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. Materials and method: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. Results: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. Discussion: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.

KW - Adult

KW - Age of Onset

KW - Body Mass Index

KW - Cross-Sectional Studies

KW - Female

KW - Hidradenitis Suppurativa/classification

KW - Humans

KW - Male

KW - Obesity/complications

KW - Protective Factors

KW - Risk Factors

KW - Severity of Illness Index

KW - Smoking

KW - Young Adult

U2 - 10.1111/jdv.14599

DO - 10.1111/jdv.14599

M3 - Journal article

C2 - 28940801

SN - 0926-9959

VL - 32

SP - 307

EP - 312

JO - Journal of the European Academy of Dermatology and Venereology : JEADV

JF - Journal of the European Academy of Dermatology and Venereology : JEADV

IS - 2

ER -