Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period

TY - JOUR

T1 - Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period

AU - Noehr, Bugge

AU - Jensen, Allan

AU - Frederiksen, Kirsten

AU - Tabor, Ann

AU - Kjaer, Susanne K

N1 - Keywords: Adult; Cervix Uteri; Electrosurgery; Female; Humans; Infant, Newborn; Infant, Premature; Obstetric Labor, Premature; Obstetric Surgical Procedures; Pregnancy; Registries; Risk Assessment; Risk Factors

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: Our aim was to assess the association between loop electrosurgical excision procedure (LEEP) and the subsequent risk for spontaneous preterm delivery, with the use of population-based data from various nationwide registries. STUDY DESIGN: The study population consisted of all singleton deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries that included different cervical procedures was obtained from various national registries. In all, 552,678 deliveries were eligible for analyses. RESULTS: Of the deliveries in which the mother had no previous LEEP, 18,519 deliveries (3.5%) were preterm; when this data were applied to 530 preterm deliveries (6.9%) that were subsequent to LEEP, the yield was a significantly increased risk of preterm delivery, with an odds ratio of 2.07 (95% CI, 1.88-2.27; LEEP vs no LEEP). CONCLUSION: Our study showed an overall 2-fold increase in the risk of spontaneous preterm delivery in singleton deliveries subsequent to LEEP treatment, even after adjustment for various potential risk factors.

AB - OBJECTIVE: Our aim was to assess the association between loop electrosurgical excision procedure (LEEP) and the subsequent risk for spontaneous preterm delivery, with the use of population-based data from various nationwide registries. STUDY DESIGN: The study population consisted of all singleton deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries that included different cervical procedures was obtained from various national registries. In all, 552,678 deliveries were eligible for analyses. RESULTS: Of the deliveries in which the mother had no previous LEEP, 18,519 deliveries (3.5%) were preterm; when this data were applied to 530 preterm deliveries (6.9%) that were subsequent to LEEP, the yield was a significantly increased risk of preterm delivery, with an odds ratio of 2.07 (95% CI, 1.88-2.27; LEEP vs no LEEP). CONCLUSION: Our study showed an overall 2-fold increase in the risk of spontaneous preterm delivery in singleton deliveries subsequent to LEEP treatment, even after adjustment for various potential risk factors.

U2 - 10.1016/j.ajog.2009.02.004

DO - 10.1016/j.ajog.2009.02.004

M3 - Journal article

C2 - 19345930

SN - 0002-9378

VL - 201

SP - 33.e1-6

JO - American Journal of Obstetrics & Gynecology

JF - American Journal of Obstetrics & Gynecology

IS - 1

ER -