Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

Hanna Jokinen; Hely Kalska; Raija Ylikoski; Sofia Madureira; Ana Verdelho; Wiesje M van der Flier; Philip Scheltens; Frederik Barkhof; Marieke C Visser; Franz Fazekas; Reinhold Schmidt; John O'Brien; Gunhild Waldemar; Anders Wallin; Hugues Chabriat; Leonardo Pantoni; Domenico Inzitari; Timo Erkinjuntti; LADIS group

doi:10.1159/000207442

Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

Hanna Jokinen, Hely Kalska, Raija Ylikoski, Sofia Madureira, Ana Verdelho, Wiesje M van der Flier, Philip Scheltens, Frederik Barkhof, Marieke C Visser, Franz Fazekas, Reinhold Schmidt, John O'Brien, Gunhild Waldemar, Anders Wallin, Hugues Chabriat, Leonardo Pantoni, Domenico Inzitari, Timo Erkinjuntti, LADIS group

127 Citations (Scopus)

Abstract

BACKGROUND: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. METHODS: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. RESULTS: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared to the reference group. The subjects with SIVD presented significantly steeper decline of performance in the Stroop test (parts I and II), Trail Making A test, Verbal fluency test, and Mini-Mental State Examination. They also had a threefold risk of developing dementia during follow-up independently of age, sex, education and medial temporal lobe atrophy. CONCLUSIONS: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive control, and global cognitive function.

Original language	English
Journal	Cerebrovascular Diseases
Volume	27
Issue number	4
Pages (from-to)	384-91
Number of pages	7
ISSN	1015-9770
DOIs	https://doi.org/10.1159/000207442
Publication status	Published - 2009

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Jokinen, H., Kalska, H., Ylikoski, R., Madureira, S., Verdelho, A., van der Flier, W. M., Scheltens, P., Barkhof, F., Visser, M. C., Fazekas, F., Schmidt, R., O'Brien, J., Waldemar, G., Wallin, A., Chabriat, H., Pantoni, L., Inzitari, D., Erkinjuntti, T., & LADIS group (2009). Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study. Cerebrovascular Diseases, 27(4), 384-91. https://doi.org/10.1159/000207442

Jokinen, H, Kalska, H, Ylikoski, R, Madureira, S, Verdelho, A, van der Flier, WM, Scheltens, P, Barkhof, F, Visser, MC, Fazekas, F, Schmidt, R, O'Brien, J, Waldemar, G, Wallin, A, Chabriat, H, Pantoni, L, Inzitari, D, Erkinjuntti, T & LADIS group 2009, 'Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study', Cerebrovascular Diseases, vol. 27, no. 4, pp. 384-91. https://doi.org/10.1159/000207442

@article{0578f8a068a911df928f000ea68e967b,

title = "Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study",

abstract = "BACKGROUND: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. METHODS: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. RESULTS: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared to the reference group. The subjects with SIVD presented significantly steeper decline of performance in the Stroop test (parts I and II), Trail Making A test, Verbal fluency test, and Mini-Mental State Examination. They also had a threefold risk of developing dementia during follow-up independently of age, sex, education and medial temporal lobe atrophy. CONCLUSIONS: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive control, and global cognitive function.",

author = "Hanna Jokinen and Hely Kalska and Raija Ylikoski and Sofia Madureira and Ana Verdelho and {van der Flier}, {Wiesje M} and Philip Scheltens and Frederik Barkhof and Visser, {Marieke C} and Franz Fazekas and Reinhold Schmidt and John O'Brien and Gunhild Waldemar and Anders Wallin and Hugues Chabriat and Leonardo Pantoni and Domenico Inzitari and Timo Erkinjuntti and {LADIS group}",

note = "Keywords: Aged; Aged, 80 and over; Brain; Cognition; Dementia; Dementia, Vascular; Europe; Female; Follow-Up Studies; Humans; Incidence; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Predictive Value of Tests; Psychomotor Performance; Risk Factors",

year = "2009",

doi = "10.1159/000207442",

language = "English",

volume = "27",

pages = "384--91",

journal = "Cerebrovascular Diseases",

issn = "1015-9770",

publisher = "S Karger AG",

number = "4",

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TY - JOUR

T1 - Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

AU - Jokinen, Hanna

AU - Kalska, Hely

AU - Ylikoski, Raija

AU - Madureira, Sofia

AU - Verdelho, Ana

AU - van der Flier, Wiesje M

AU - Scheltens, Philip

AU - Barkhof, Frederik

AU - Visser, Marieke C

AU - Fazekas, Franz

AU - Schmidt, Reinhold

AU - O'Brien, John

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Chabriat, Hugues

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Erkinjuntti, Timo

AU - LADIS group

N1 - Keywords: Aged; Aged, 80 and over; Brain; Cognition; Dementia; Dementia, Vascular; Europe; Female; Follow-Up Studies; Humans; Incidence; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Predictive Value of Tests; Psychomotor Performance; Risk Factors

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. METHODS: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. RESULTS: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared to the reference group. The subjects with SIVD presented significantly steeper decline of performance in the Stroop test (parts I and II), Trail Making A test, Verbal fluency test, and Mini-Mental State Examination. They also had a threefold risk of developing dementia during follow-up independently of age, sex, education and medial temporal lobe atrophy. CONCLUSIONS: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive control, and global cognitive function.

AB - BACKGROUND: Cross-sectional studies have indicated that subcortical ischemic vascular disease (SIVD), as defined according to imaging criteria, is associated with a specific clinical and cognitive profile. Much less is known about the long-term cognitive consequences of SIVD. The aim of the study was to investigate the longitudinal cognitive performance and incident dementia in subjects with and without SIVD in a sample of older adults with white matter lesions. METHODS: In the Leukoaraiosis and Disability (LADIS) study, 639 participants were examined with annual clinical and neuropsychological evaluations for 3 years. The subjects meeting the MRI criteria of SIVD at baseline were compared to the other subjects of the sample with linear mixed models. RESULTS: The overall level of cognitive performance over the follow-up period was inferior in multiple cognitive domains in SIVD subjects as compared to the reference group. The subjects with SIVD presented significantly steeper decline of performance in the Stroop test (parts I and II), Trail Making A test, Verbal fluency test, and Mini-Mental State Examination. They also had a threefold risk of developing dementia during follow-up independently of age, sex, education and medial temporal lobe atrophy. CONCLUSIONS: SIVD, as a manifestation of cerebral small vessel disease, is related to progressive cognitive impairment and a considerable risk of developing dementia. SIVD seems to specifically contribute to the deterioration of psychomotor speed, executive control, and global cognitive function.

U2 - 10.1159/000207442

DO - 10.1159/000207442

M3 - Journal article

C2 - 19276621

SN - 1015-9770

VL - 27

SP - 384

EP - 391

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

IS - 4

ER -

Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

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